{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:59:00Z","timestamp":1763765940908},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,7,17]],"date-time":"2012-07-17T00:00:00Z","timestamp":1342483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>Kanagal\u2010Shamanna R, Medeiros L J, Lu G, Wang S A, Manning J T, Lin P, Penn G M, Young K H, You M J, Vega F, Bassett R &amp; Miranda R N \u2028(2012) <jats:italic>Histopathology<\/jats:italic>\u00a0<jats:bold>61,<\/jats:bold> 945\u2013954<\/jats:p><jats:p><jats:bold>High\u2010grade B cell lymphoma, unclassifiable, with blastoid features: an unusual morphological subgroup associated frequently with <jats:italic>BCL2<\/jats:italic> and\/or <jats:italic>MYC<\/jats:italic> gene rearrangements and a poor prognosis<\/jats:bold><\/jats:p><jats:p><jats:bold>Aims:\u2002<\/jats:bold> A subset of B cell lymphomas with blastoid features do not fit either as B lymphoblastic lymphoma\/leukaemia or blastoid mantle cell lymphoma. Their classification is challenging, even with complete clinicopathological and genetic information. At a haematopathology workshop, experts had suggested the term \u2018high\u2010grade B cell lymphoma, unclassifiable, with blastoid features\u2019, and recommended further studies.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> We describe the clinicopathological, immunophenotypic and cytogenetic findings of 24 high\u2010grade B cell lymphomas, unclassifiable, with blastoid features. Fifteen patients presented <jats:italic>de novo<\/jats:italic> and seven patients had a history of lymphoma. Twenty patients (83%) presented with nodal disease. All tumours expressed pan\u2010B cell antigens and 17 (89%) of 19 tumours assessed had a germinal centre B cell immunophenotype. Ten (63%) of 16 tumours assessed by fluorescence <jats:italic>in\u2010situ<\/jats:italic> hybridization (FISH) had <jats:italic>MYC<\/jats:italic> rearrangement, 13 of 18 (72%) carried <jats:italic>IGH<\/jats:italic>\u2010<jats:italic>BCL2<\/jats:italic> and nine of 15 (60%) had both (double\u2010hit lymphoma). The median overall survival was 1.1\u2003years. Using 2008 World Health Organization criteria, 15 cases were classified as B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma (DLBCL) and Burkitt lymphoma, and nine as DLBCL, small centroblastic variant.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> High\u2010grade B cell lymphomas, unclassifiable, with blastoid features are clinically aggressive with poor survival. Most neoplasms have a germinal centre B cell phenotype. <jats:italic>MYC<\/jats:italic> rearrangements and <jats:italic>IGH\u2010BCL2<\/jats:italic> are common, and \u223c60% are double\u2010hit lymphomas.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2012.04301.x","type":"journal-article","created":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T15:43:12Z","timestamp":1334936592000},"page":"945-954","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["High\u2010grade B cell lymphoma, unclassifiable, with blastoid features: an unusual morphological subgroup associated frequently with <i>BCL2<\/i> and\/or <i>MYC<\/i> gene rearrangements and a poor prognosis"],"prefix":"10.1111","volume":"61","author":[{"given":"Rashmi","family":"Kanagal\u2010Shamanna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sa A","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T","family":"Manning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald M","family":"Penn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken H","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M James","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Vega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Bassett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto N","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,17]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"168","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Borowitz MJ","year":"2008"},{"key":"e_1_2_6_3_2","first-page":"229","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02068.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1309\/HRHQFBFTR8B4LXT4"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/S0046-8177(03)00412-X"},{"key":"e_1_2_6_7_2","volume-title":"ISCN (2009): Recommendations of the International Standing Committee on Human Cytogenetic Nomenclature","author":"Shaffer LG","year":"2009"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1545"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.83"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2011.1.506"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-297879"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.147"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cd3aeb"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/35000501"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012914"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000172191.87176.3b"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200004000-00006"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-011-1162-y"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(00)00383-6"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.10.7896"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.039263"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/110.2.143"},{"key":"e_1_2_6_23_2","first-page":"1211","article-title":"The immunophenotype of blast transformation of chronic myelogenous leukemia: a high frequency of mixed lineage phenotype in \u2018lymphoid\u2019 blasts and a comparison of morphologic, immunophenotypic, and molecular findings","volume":"11","author":"Khalidi HS","year":"1998","journal-title":"Mod. 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