{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:54:56Z","timestamp":1787014496578,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,8,8]],"date-time":"2012-08-08T00:00:00Z","timestamp":1344384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>\n                    Tsai J\u2010H, Huang W\u2010C, Kuo K\u2010T, Yuan R\u2010H, Chen Y\u2010L &amp; Jeng Y\u2010M \u2028(2012)\n                    <jats:italic>Histopathology<\/jats:italic>\n                    \u2028\n                    <jats:bold>S100P immunostaining identifies a subset of peripheral\u2010type intrahepatic cholangiocarcinomas with morphological and molecular features similar to those of perihilar and extrahepatic cholangiocarcinomas<\/jats:bold>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aims:\u2002<\/jats:bold>\n                    S100P is a calcium\u2010binding protein that is frequently expressed in pancreatic adenocarcinoma and perihilar cholangiocarcinoma. The aim of this study was to investigate the pathological significance of the expression of S100P in peripheral intrahepatic cholangiocarcinoma (ICC).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods and results:\u2002<\/jats:bold>\n                    Immunohistochemical staining was used to investigate S100P expression in 112 cases of peripheral ICC. The results were compared with those for perihilar and extrahepatic cholangiocarcinomas. Patients with S100P\u2010positive peripheral ICC were more likely to have elevated serum levels of carcinoembryonic antigen (CEA) and CA19\u20109 than those with S100P\u2010negative peripheral ICCs. All cases of peripheral ICC associated with intrahepatic lithiasis and all cases with intraductal\/periductal growth patterns were positive for S100P. S100P\u2010positive peripheral ICCs were highly associated with \u2018bile duct\u2019 morphology rather than cholangiolar differentiation. Nearly all cases of perihilar and extrahepatic cholangiocarcinoma were positive for S100P. Similarly to perihilar and extrahepatic cholangiocarcinomas, S100P\u2010positive peripheral ICCs showed more frequent expression of CEA and MUC2, and were more likely to be N\u2010cadherin\u2010negative, than S100P\u2010negative cases. Notably,\n                    <jats:italic>K\u2010RAS<\/jats:italic>\n                    mutations were only detected in S100P\u2010positive peripheral ICCs, with a frequency similar to that in perihilar and extrahepatic cholangiocarcinomas. Patients with S100P\u2010positive peripheral ICC were more likely to have poor prognoses than those with S100P\u2010negative tumours.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    S100P immunostaining identifies a subset of peripheral ICC that probably originates from larger bile ducts. This subset of peripheral ICCs shares common morphological and molecular features with perihilar and extrahepatic cholangiocarcinomas.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2559.2012.04316.x","type":"journal-article","created":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T11:24:37Z","timestamp":1335525877000},"page":"1106-1116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["S100P immunostaining identifies a subset of peripheral\u2010type intrahepatic cholangiocarcinomas with morphological and molecular features similar to those of perihilar and extrahepatic cholangiocarcinomas"],"prefix":"10.1111","volume":"61","author":[{"given":"Jia\u2010Huei","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Chih","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan\u2010Ting","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray\u2010Hwang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung\u2010Ming","family":"Jeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,8]]},"reference":[{"key":"e_1_2_8_2_2","volume-title":"World Health Organization classification of tumours of the digestive system","author":"Bosman FT","year":"2010"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-2-10"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2002.02781.x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.41"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-002-0732-8"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2001.00775.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.28199"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90755-3"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31802b34b6"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1992.tb17080.x"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.2741\/223"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.10.082"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.036848"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-2004"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.07.011"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2605"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310124200"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E02-09-0553"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0092"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62234-1"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31820ffdf1"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2010.01757.x"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2005.01816.x"},{"key":"e_1_2_8_26_2","first-page":"9","article-title":"The diagnostic value of cytokeratins and carcinoembryonic antigen immunostaining in differentiating hepatocellular carcinomas from intrahepatic cholangiocarcinomas","volume":"15","author":"Stroescu C","year":"2006","journal-title":"J. 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