{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:12:20Z","timestamp":1768288340654,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,10]],"date-time":"2012-09-10T00:00:00Z","timestamp":1347235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>Liu F, Asano N, Tatematsu A, Oyama T, Kitamura K, Suzuki K, Yamamoto K, Sakamoto N, Taniwaki M, Kinoshita T &amp; Nakamura S \u2028(2012) <jats:italic>Histopathology<\/jats:italic>\u2028<jats:bold>Plasmablastic lymphoma of the elderly: a clinicopathological comparison with age\u2010related Epstein\u2013Barr virus\u2010associated B cell lymphoproliferative disorder<\/jats:bold><\/jats:p><jats:p><jats:bold>Aims:\u2002<\/jats:bold> Plasmablastic lymphoma (PBL) is an aggressive lymphoma with a terminally differentiated B cell phenotype; half of patients with this disease have Epstein\u2013Barr virus (EBV) infection. The majority of PBL cases are associated with human immunodeficiency virus (HIV) infection, while the remaining HIV\u2010negative cases were accompanied by other immunodeficiency conditions or immunosenescence in the elderly.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> To characterize HIV\u2010negative PBL of the elderly (PBL\u2010E), we compared the clinicopathological characteristics of 10 cases of PBL\u2010E and 124 cases with age\u2010related EBV\u2010associated B cell lymphoproliferative disorder (AR\u2010EBVLPD). The 10 PBL\u2010E (eight men, two women; median age: 68\u2003years) were associated with a more indolent clinical behaviour and a better overall survival than AR\u2010EBVLPD. Extranodal involvement was higher in PBL\u2010E (50%) than AR\u2010EBVLPD; notably, the nasal cavity was affected most frequently in PBL\u2010E (60%). Immunoglobulin heavy chain\/(IGH)\/MYC translocation was detected in half of the PBL\u2010E cases.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> PBL\u2010E shares some clinical features with AR\u2010EBVLPD, such as HIV negativity, old age, and EBV infection, no known immunosuppressive condition but there are some differences such as a higher ratio of extranodal involvement and better prognosis. PBL\u2010E is a newly recognized condition and should be distinguished from HIV\u2010positive PBL, sharing features with AR\u2010EBVLPD in particular, immunosenescence of the elderly.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2012.04339.x","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T18:21:24Z","timestamp":1339438884000},"page":"1183-1197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Plasmablastic lymphoma of the elderly: a clinicopathological comparison with age\u2010related Epstein\u2013Barr virus\u2010associated B cell lymphoproliferative disorder"],"prefix":"10.1111","volume":"61","author":[{"given":"Fang","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Asano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Tatematsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Oyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunio","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhito","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsumi","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Taniwaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.4.1413"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.516040"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000126781.87158.e3"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2010.10.007"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-164806"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200301000-00003"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2823"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-323238"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cf8622"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2007.05.002"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2009.02466.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.5342"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-003-0684-3"},{"key":"e_1_2_7_15_2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.5858\/2004-128-581-PLOTCL","article-title":"Plasmablastic lymphoma of the cervical lymph nodes in a human immunodeficiency virus\u2010negative patient: a case report and review of the literature","volume":"128","author":"Lin F","year":"2004","journal-title":"Arch. 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