{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T14:26:48Z","timestamp":1785680808084,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,9,28]],"date-time":"2012-09-28T00:00:00Z","timestamp":1348790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:bold>Aims:\u2002<\/jats:bold> Occasional cases of well\u2010differentiated and dedifferentiated liposarcoma (LPS) contain myxoid stroma, leading to confusion with other sarcomas. The aim of this study was to analyse the clinicopathological and genetic features of well\u2010differentiated\/dedifferentiated LPS with prominent myxoid stroma.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> Fifty\u2010six cases of LPS (22 well\u2010differentiated; 34 dedifferentiated) with prominent myxoid stroma were evaluated. Most arose in the retroperitoneum, abdominal cavity, or spermatic cord. The mean size was 170\u2003mm. Myxoid LPS\u2010like plexiform vessels were conspicuous in 11 cases of well\u2010differentiated LPS. In 22 cases of dedifferentiated LPS, myxofibrosarcoma\u2010like curvilinear vessels were prominent. In other cases, the myxoid component had variably bland or pleomorphic morphology. By immunohistochemistry, staining for MDM2 was positive in 95% of cases, and CDK4 in 78%. Cytogenetics in 13 cases showed ring and giant marker chromosomes. Fluorescence <jats:italic>in\u2010situ<\/jats:italic> hybridization showed amplification of 12q13\u201315 in six cases evaluated. Of 30 patients with follow\u2010up, all but one had local recurrences (up to four), but only one has so far had distant metastases.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Well\u2010differentiated\/dedifferentiated LPS with prominent myxoid stroma can closely resemble other sarcoma types, especially myxoid LPS and myxofibrosarcoma. The clinical presentation (large retroperitoneal or abdominal tumour) is a clue to the correct diagnosis; the degree of nuclear atypia helps to exclude myxoid LPS. Immunohistochemistry for MDM2 and CDK4 and genetic analysis can be useful to confirm the diagnosis.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2012.04348.x","type":"journal-article","created":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T19:29:43Z","timestamp":1340047783000},"page":"287-293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Well\u2010differentiated and dedifferentiated liposarcomas with prominent myxoid stroma: analysis of 56 cases"],"prefix":"10.1111","volume":"62","author":[{"given":"Stefano","family":"Sioletic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Dal Cin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D M","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason L","family":"Hornick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,28]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"World Health Organization classification of tumours: pathology and genetics of tumours of soft tissue and bone","author":"Fletcher CD","year":"2002"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-197912000-00004"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199703000-00002"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199411000-00009"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-009-0815-x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200004)190:5<531::AID-PATH579>3.0.CO;2-W"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3180581fff"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/363640a0"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-1578(10)60628-9"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199805)22:1<16::AID-GCC3>3.0.CO;2-A"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000170343.09562.39"},{"key":"e_1_2_5_13_2","first-page":"623","article-title":"Correlation between clinicopathological features and karyotype in lipomatous tumors. A report of 178 cases from the Chromosomes and Morphology (CHAMP) Collaborative Study Group","volume":"148","author":"Fletcher CD","year":"1996","journal-title":"Am. J. 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