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In this study, we investigated whether whole\u2010cell <jats:italic>B. pertussis<\/jats:italic> could inhibit allergic airway reactions in a murine model of asthma induced by ovalbumin (OVA). Systemic administration of whole\u2010cell <jats:italic>B. pertussis<\/jats:italic> strongly inhibited allergic airway reactions such as eosinophil recruitment into the airway, lung inflammation, and airway hyperresponsiveness to methacholine. The inhibitory effect of whole\u2010cell <jats:italic>B. pertussis<\/jats:italic> was mediated by chromosomal DNA and pretreatment of DNA with CpG methylase or DNase I resulted in a loss of the inhibitory effect. Treatment of animals with <jats:italic>B. pertussis<\/jats:italic> DNA significantly decreased the Th2 cytokine (interleukins IL\u20104 and IL\u20105) concentrations in the airways without increasing Th1 cytokines. These results suggest that <jats:italic>B. pertussis<\/jats:italic> DNA containing unmethylated CpG appears to be responsible for the inhibitory effect of whole cell <jats:italic>B. pertussis<\/jats:italic> on the allergic airway reactions through inhibition of the Th2 response.<\/jats:p>","DOI":"10.1111\/j.1365-2567.2004.01880.x","type":"journal-article","created":{"date-parts":[[2004,12,27]],"date-time":"2004-12-27T01:03:55Z","timestamp":1104109435000},"page":"624-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Inhibition of murine allergic airway disease by <i>Bordetella 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