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When compared with carrageenan\u2010treated young rats (3\u2003months old), old rats (&gt;\u200318\u2003months old) exhibited a preponderance of pleural exudation and polymorphonuclear cell infiltration. Lung myeloperoxidase activity, an index of neutrophil infiltration and activation, was significantly increased in old rats in comparison with young rats. Consistent with the biochemical markers of inflammation, increased lung damage, as assessed by nitrosative stress and lipid peroxidation, was observed in carrageenan\u2010treated old rats. In the lung exudate obtained from old rats, a significant reduction in interleukin\u201010 (IL\u201010) was observed, while similar expression of monocyte chemotactic protein\u20101 was induced, suggesting that a decrease in IL\u201010 rather than increased chemotaxis may account for the preponderance of the inflammatory cellular infiltrate in old rats. Similar to the <jats:italic>in vivo<\/jats:italic> situation, freshly isolated alveolar macrophages obtained from old rats produced less IL\u201010. This defective IL\u201010 production could be explained by a reduction in the cAMP\u2010dependent signalling pathway, which mediates IL\u201010 production. Indeed, we found decreased cAMP\u2010responsive element binding protein (CREB) and phosphorous\u2010CREB (P\u2010CREB) expression in old rats, which may account for reduced IL\u201010 production in old rats.<\/jats:p>","DOI":"10.1111\/j.1365-2567.2005.02148.x","type":"journal-article","created":{"date-parts":[[2005,5,10]],"date-time":"2005-05-10T13:09:57Z","timestamp":1115730597000},"page":"253-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Increased carrageenan\u2010induced acute lung inflammation in old rats"],"prefix":"10.1111","volume":"115","author":[{"given":"Emanuela","family":"Corsini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna","family":"Di 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