{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:54:21Z","timestamp":1793476461809,"version":"4.5.0"},"reference-count":67,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T00:00:00Z","timestamp":1114560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Secretion of immunomodulatory molecules is a key strategy employed by pathogens to enable their survival in host organisms. For example, arthropod\u2010transmitted filarial nematodes, which achieve longevity within the infected host by suppressing and modulating the host immune response, produce excretory\u2013secretory (ES) products that have been demonstrated to possess immunomodulatory properties. In this review we discuss the immunomodulatory effects of the phosphorylcholine\u2010containing filarial nematode\u2010secreted glycoprotein ES\u201062 and describe the intracellular signal transduction pathways it targets to achieve these effects.<\/jats:p>","DOI":"10.1111\/j.1365-2567.2005.02167.x","type":"journal-article","created":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T10:34:58Z","timestamp":1118313298000},"page":"296-304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES\u201062"],"prefix":"10.1111","volume":"115","author":[{"given":"Helen S.","family":"Goodridge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Stepek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Harnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Harnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,9]]},"reference":[{"key":"e_1_2_8_2_2","volume-title":"Filariasis.","author":"WHO.","year":"2000"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182004004822"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2001.00395.x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2003.11.003"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2001.00397.x"},{"key":"e_1_2_8_7_2","first-page":"207","volume-title":"Perspectives in Nematode Physiology and Biochemistry.","author":"Harnett W","year":"1995"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(01)00481-2"},{"key":"e_1_2_8_9_2","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.4049\/jimmunol.150.9.3941","article-title":"Differential expression of IgE and IgG4 specific antibody responses in asymptomatic and chronic human filariasis","volume":"150","author":"Kurniawan A","year":"1993","journal-title":"J Immunol"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1995.tb00906.x"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/173.3.769"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1997.d01-185.x"},{"key":"e_1_2_8_13_2","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.4049\/jimmunol.127.4.1623","article-title":"IgE responses in human filariasis. I. Quantitation of filaria\u2010specific IgE","volume":"127","author":"Hussain R","year":"1981","journal-title":"J Immunol"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000058686"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182002001920"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182003004220"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389203033380368"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(99)00113-9"},{"key":"e_1_2_8_19_2","first-page":"167","article-title":"Aminopeptidases: towards a mechanism of action","volume":"18","author":"Taylor A","year":"1993","journal-title":"Trends Biochem Sci"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.2307\/3284518"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1993.1113"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(03)74868-1"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(98)01419-4"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1999.00267.x"},{"key":"e_1_2_8_25_2","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.4049\/jimmunol.151.9.4829","article-title":"Inhibition of murine B cell proliferation and down\u2010regulation of protein kinase C levels by a phosphorylcholine\u2010containing filarial excretory\u2010secretory product","volume":"151","author":"Harnett W","year":"1993","journal-title":"J Immunol"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1998.00181.x"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2003.01661.x"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2003.00650.x"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.12.6453"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.9.5466-5468.2000"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.2.940"},{"key":"e_1_2_8_32_2","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.4049\/jimmunol.138.10.3454","article-title":"Circulating parasite antigen (s) in lymphatic filariasis: use of monoclonal antibodies to phosphocholine for immunodiagnosis","volume":"138","author":"Lal RB","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000060637"},{"key":"e_1_2_8_34_2","doi-asserted-by":"crossref","first-page":"6105","DOI":"10.4049\/jimmunol.159.12.6105","article-title":"A filarial nematode secreted product differentially modulates expression and activation of protein kinase C isoforms in B lymphocytes","volume":"159","author":"Deehan MR","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/10.1.17"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.2.687"},{"key":"e_1_2_8_37_2","first-page":"195","volume-title":"Parasitic Nematodes \u2013 Antigens, Membranes and Genes","author":"Harnett W","year":"1991"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2003.01689.x"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2004.01993.x"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.1.284"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.12.6723"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(94)90267-4"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.002325"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(94)90039-6"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/7.2.151"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.7.2279"},{"key":"e_1_2_8_47_2","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.4049\/jimmunol.143.3.1032","article-title":"Induction of c\u2010fos and c\u2010myc expression during B cell activation by IL\u20104 and immunoglobulin binding ligands","volume":"143","author":"Klemsz MJ","year":"1989","journal-title":"J Immunol"},{"key":"e_1_2_8_48_2","doi-asserted-by":"crossref","first-page":"4822","DOI":"10.4049\/jimmunol.150.11.4822","article-title":"Induction of early response genes by cross\u2010linking membrane Ig on B lymphocytes","volume":"150","author":"Mittelstadt PR","year":"1993","journal-title":"J Immunol"},{"key":"e_1_2_8_49_2","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.4049\/jimmunol.145.11.3647","article-title":"Egr\u20101 expression in surface Ig\u2010mediated B cell activation. Kinetics and association with protein kinase C activation","volume":"145","author":"Seyfert VL","year":"1990","journal-title":"J Immunol"},{"key":"e_1_2_8_50_2","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.4049\/jimmunol.160.6.2692","article-title":"A phosphorylcholine\u2010containing filarial nematode\u2010secreted product disrupts B lymphocyte activation by targeting key proliferative signaling pathways","volume":"160","author":"Deehan MR","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.12.7462"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2004.05.014"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.47.27995"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.1.466"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb00306.x"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00540-7"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(99)80042-9"},{"key":"e_1_2_8_58_2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4269\/ajtmh.1990.42.56","article-title":"Phosphocholine\u2010containing antigens of Brugia malayi nonspecifically suppress lymphocyte function","volume":"42","author":"Lal RB","year":"1990","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141126"},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(03)00115-7"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1391"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300738200"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000079340.80744.B8"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209634200"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182096008402"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.4.2127"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/7.5.633"},{"key":"e_1_2_8_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(99)77443-6"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2567.2005.02167.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2567.2005.02167.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T09:20:26Z","timestamp":1697188826000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2567.2005.02167.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,9]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["10.1111\/j.1365-2567.2005.02167.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2567.2005.02167.x","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,9]]},"assertion":[{"value":"2005-06-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}