{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:54:30Z","timestamp":1789908870216,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,2,20]],"date-time":"2006-02-20T00:00:00Z","timestamp":1140393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The role of type I interferon (IFN\u2010\u03b1\u03b2) in modulating innate or adaptive immune responses against mycobacterial infection in the lung is unclear. In this study we investigated the susceptibility of IFN\u2010\u03b1\u03b2\u2010receptor\u2010deficient (IFN\u2010\u03b1\u03b2R<jats:sup>\u2013\/\u2013<\/jats:sup>) mice to pulmonary infection with aerosolized <jats:italic>Mycobacterium bovis<\/jats:italic> bacillus Calmette\u2013Gu\u00e9rin (BCG). During early infection (2\u20133\u2003weeks), enhanced growth of BCG was measured in the lungs of IFN\u2010\u03b1\u03b2R<jats:sup>\u2013\/\u2013<\/jats:sup> mice compared to wild\u2010type mice. However, during late infection the burden of BCG was similar in the lungs of IFN\u2010\u03b1\u03b2R<jats:sup>\u2013\/\u2013<\/jats:sup> and wild\u2010type mice. Although control of BCG growth was delayed, recruitment and activation of T and natural killer cells, production of IFN\u2010\u03b3, and cytokine expression were all similar in wild\u2010type and IFN\u2010\u03b1\u03b2R<jats:sup>\u2013\/\u2013<\/jats:sup> mice. However, decreased expression of nitric oxide in bronchoalveolar lavage fluids from IFN\u2010\u03b1\u03b2R<jats:sup>\u2013\/\u2013<\/jats:sup> mice correlated with enhanced growth of BCG. Bone marrow\u2010derived macrophages from IFN\u2010\u03b1\u03b2R<jats:sup>\u2013\/\u2013<\/jats:sup> mice also produced less nitric oxide following infection with BCG <jats:italic>in vitro<\/jats:italic>. These findings suggest that IFN\u2010\u03b1\u03b2 contributes to innate immunity to pulmonary mycobacterial infection by augmenting production of nitric oxide.<\/jats:p>","DOI":"10.1111\/j.1365-2567.2006.02337.x","type":"journal-article","created":{"date-parts":[[2006,2,20]],"date-time":"2006-02-20T16:28:12Z","timestamp":1140452892000},"page":"39-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Interferon\u2010\u03b1\u03b2 mediates partial control of early pulmonary <i>Mycobacterium bovis<\/i> bacillus Calmette\u2013Gu\u00e9rin infection"],"prefix":"10.1111","volume":"118","author":[{"given":"John","family":"Kuchtey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Fulton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Reba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford V.","family":"Harding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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