{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:28:42Z","timestamp":1791217722285,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,9,21]],"date-time":"2006-09-21T00:00:00Z","timestamp":1158796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Professional antigen\u2010presenting cells (APC) are able to process and present exogenous antigen leading to the activation of T cells. Antigen\u2013immunoglobulin (Ig)G complexes (IC) are much more efficiently processed and presented than soluble antigen. Dendritic cells (DC) are known for their ability to take up and process immune complex (IC) via Fc\u03b3R, and they have been shown to play a crucial role in IC\u2010processing onto major histocompatibility complex (MHC) class I as they contain a specialized cross\u2010presenting transport system required for MHC class I antigen\u2010processing. However, the MHC class II\u2010antigen\u2010processing pathway is distinct. Therefore various other professional APC, like macrophages and B cells, all displaying Fc\u03b3R, are thought to present IC\u2010delivered antigen in MHC class II. Nonetheless, the relative contribution of these APC in IC\u2010facilitated antigen\u2010presentation for MHC class II\n                    <jats:italic>in vivo<\/jats:italic>\n                    is not known. Here we show that, in mice, both macrophages and DC, but not B cells, efficiently capture IC. However, only DC, but not macrophages, efficiently activate antigen\u2010specific MHC class II restricted CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells. These results indicate that mainly DC and not other professional APC, despite expressing Fc\u03b3R and MHC class II, contribute significantly to IC\u2010facilitated T cell activation\n                    <jats:italic>in vivo<\/jats:italic>\n                    under steady\u2010state conditions.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2567.2006.02464.x","type":"journal-article","created":{"date-parts":[[2006,9,21]],"date-time":"2006-09-21T11:19:10Z","timestamp":1158837550000},"page":"499-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Dendritic cells, but not macrophages or B cells, activate major histocompatibility complex class II\u2010restricted CD4\n                    <sup>+<\/sup>\n                    T cells upon immune\u2010complex uptake\n                    <i>in vivo<\/i>"],"prefix":"10.1111","volume":"119","author":[{"given":"Judith M. H.","family":"De Jong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danita H.","family":"Schuurhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Ioan\u2010Facsinay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mick M.","family":"Welling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel G. M.","family":"Camps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen I. H.","family":"Van Der Voort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom W. 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