{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T07:37:07Z","timestamp":1782805027150,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T00:00:00Z","timestamp":1162252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>BAFF\u2010R is the predominant receptor that mediates B\u2010cell activating factor (BAFF)\u2010dependent B\u2010cell signalling and plays a critical role in late\u2010stage B\u2010cell maturation and survival. BAFF has been implicated in the development of autoimmunity and systemic lupus erythematosus (SLE). To define the role of BAFF\u2010R in autoimmunity and SLE, we crossed A\/WySnJ mice with MRL\u2010<jats:italic>lpr<\/jats:italic>mice and generated BAFF\u2010R\u2010mutant MRL\u2010<jats:italic>lpr<\/jats:italic>mice. The BAFF\u2010R mutation markedly impaired the development of immature, mature and marginal zone B cells in the spleens of MRL\u2010<jats:italic>lpr<\/jats:italic>mice. Unexpectedly, the BAFF\u2010R mutation in MRL\u2010<jats:italic>lpr<\/jats:italic>mice did not result in decreased autoantibody production, hypergammaglobulinaemia or immune complex\u2010mediated glomerulonephritis. Rather, the ability of BAFF\u2010R\u2010mutant<jats:italic>lpr<\/jats:italic>splenic B cells to produce immunoglobulins<jats:italic>in vitro<\/jats:italic>was not decreased, although germinal centre formation, antibody response and B\u2010cell proliferation were impaired. Further studies found increased numbers of B cells in the bone marrow of BAFF\u2010R\u2010mutant MRL\u2010<jats:italic>lpr<\/jats:italic>mice compared to the BAFF\u2010R\u2010intact lupus mice. ELISPOT analysis revealed that BAFF\u2010R\u2010mutant MRL\u2010<jats:italic>lpr<\/jats:italic>mice had more antibody\u2010secreting cells in their bone marrow than the control mice. Thus, these findings could explain the development of autoimmunity and hypergammaglobulinaemia observed in BAFF\u2010R\u2010mutant MRL\u2010<jats:italic>lpr<\/jats:italic>mice.<\/jats:p>","DOI":"10.1111\/j.1365-2567.2006.02500.x","type":"journal-article","created":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T08:56:57Z","timestamp":1162285017000},"page":"281-289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Unexpected development of autoimmunity in BAFF\u2010R\u2010mutant MRL\u2010<i>lpr<\/i>mice"],"prefix":"10.1111","volume":"120","author":[{"given":"Zhong L.","family":"Ju","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui Y.","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin 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