{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:13:31Z","timestamp":1771006411880,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,1,8]],"date-time":"2007-01-08T00:00:00Z","timestamp":1168214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We investigated the regulation of T\u2010cell homing receptors in infectious disease by evaluating the cutaneous lymphocyte antigen (CLA) in human leprosy. We found that CLA\u2010positive cells were enriched in the infectious lesions associated with restricting the growth of the pathogen <jats:italic>Mycobacterium leprae<\/jats:italic>, as assessed by the clinical course of infection. Moreover, CLA expression on T cells isolated from the peripheral blood of antigen\u2010responsive tuberculoid leprosy patients increased in the presence of <jats:italic>M.\u2003leprae<\/jats:italic> (2\u00b74\u2010fold median increase; range 0\u00b78\u20136\u00b71, <jats:italic>n<\/jats:italic>\u2003=\u200317), but not in unresponsive lepromatous leprosy patients (1\u00b70\u2010fold median increase; range 0\u00b71\u20132\u00b72, <jats:italic>n<\/jats:italic>\u2003=\u200310; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b7005). <jats:italic>Mycobacterium leprae<\/jats:italic> specifically up\u2010regulated the skin homing receptor, CLA, but not \u03b1<jats:sub>4<\/jats:sub>\/\u03b2<jats:sub>7<\/jats:sub>, the intestinal homing receptor, which decreased on T cells of patients with tuberculoid leprosy after antigen stimulation (2\u00b72\u2010fold median decrease; range 1\u00b76\u20133\u00b74, <jats:italic>n<\/jats:italic>\u2003=\u20033). Our data indicate that CLA expression is regulated during the course of leprosy infection and suggest that T\u2010cell responsiveness to a microbial antigen directs antigen\u2010specific T cells to the site of infection.<\/jats:p>","DOI":"10.1111\/j.1365-2567.2006.02528.x","type":"journal-article","created":{"date-parts":[[2007,1,8]],"date-time":"2007-01-08T18:38:41Z","timestamp":1168281521000},"page":"518-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Regulation of human T\u2010cell homing receptor expression in cutaneous bacterial infection"],"prefix":"10.1111","volume":"120","author":[{"given":"Peter A.","family":"Sieling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annaliza","family":"Legaspi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Ochoa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Rea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Modlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,11]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1053","article-title":"A unique phenotype of skin\u2010associated lymphocytes in humans: preferential expression of the HECA\u2010452 epitope by benign and malignant T cells at cutaneous sites","volume":"136","author":"Picker LJ","year":"1990","journal-title":"Am J Pathol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"14869","DOI":"10.1016\/S0021-9258(18)98555-8","article-title":"A carbohydrate domain common to both sialyl Le(a) and sialyl Le(X) is recognized by the endothelial cell leukocyte adhesion molecule ELAM\u20101","volume":"266","author":"Berg EL","year":"1991","journal-title":"J Biol Chem"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.4049\/jimmunol.150.3.1122","article-title":"Control of lymphocyte recirculation in man. 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