{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:21:53Z","timestamp":1789849313139,"version":"4.0.1"},"reference-count":105,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,11]],"date-time":"2007-12-11T00:00:00Z","timestamp":1197331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In the early 1970s a spate of papers by research groups around the world provided evidence for a negative regulatory role of thymus\u2010derived lymphocytes (T cells). In 1971, Gershon and Kondo published a seminal paper in <jats:italic>Immunology<\/jats:italic> entitled \u2018Infectious Immunological Tolerance\u2019<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#b1\"><jats:sup>1<\/jats:sup><\/jats:ext-link> indicating that such negative regulation could be a dominant effect that prevented otherwise \u2018helpful\u2019 T cells from mediating their function. Over the next decade, suppressor T cells, as these negative regulatory cells became known, were intensively investigated and a complex set of interacting cells and soluble factors were described as mediators in this process of immune regulation. In the early 1980s, however, biochemical and molecular experiments raised questions about the interpretation of the earlier studies, and within a few years, the term \u2018suppressor T cell\u2019 had all but disappeared from prominence and research on this phenomenon was held in poor esteem. While this was happening, new studies appeared suggesting that a subset of T cells played a critical role in preventing autoimmunity. These T cells, eventually dubbed \u2018regulatory T cells\u2019, have become a major focus of modern cellular immunological investigation, with a predominance that perhaps eclipses even that seen in the earlier period of suppressor T cell ascendancy. This brief review summarizes the rise and fall of \u2018suppressorology\u2019 and the possibility that Tregs are a modern rediscovery of suppressor T cells made convincing by more robust models for their study and better reagents for their identification and analysis.<\/jats:p>","DOI":"10.1111\/j.1365-2567.2007.02779.x","type":"journal-article","created":{"date-parts":[[2008,2,8]],"date-time":"2008-02-08T15:15:20Z","timestamp":1202483720000},"page":"20-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Special regulatory T\u2010cell review: A rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasm"],"prefix":"10.1111","volume":"123","author":[{"given":"Ronald N.","family":"Germain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,11]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"903","article-title":"Infectious immunological tolerance","volume":"21","author":"Gershon RK","year":"1971","journal-title":"Immunology"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(61)90693-6"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.116.5.773"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-122-31353"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.158.3808.1573"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.128.4.821"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.4049\/jimmunol.105.6.1581","article-title":"Evidence for the existence of two functionally distinct types of cells which regulate the antibody response to type 3 pneumococcal polysaccharide","volume":"105","author":"Baker PJ","year":"1970","journal-title":"J Immunol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.4049\/jimmunol.107.6.1682","article-title":"Regulation of homocytotropic antibody formation in the rat. 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