{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:35:47Z","timestamp":1791588947385,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T00:00:00Z","timestamp":1277337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p> <jats:italic>Salmonella enterica<\/jats:italic> serovar Typhimurium (<jats:italic>S.\u00a0typhimurium<\/jats:italic>) causes a localized enteric infection and its elimination is dependent on a T helper type 1 immune response. However, the mechanism of the protective immune response against the pathogen in gut\u2010associated lymphoid tissue (GALT) at an early stage of the infection is not yet clarified. Here, we show that interleukin\u201017A (IL\u201017A) was constitutively expressed in GALT; it was also detected on crypt and epithelial cells of the small intestine. Neutralization of the IL\u201017A in the intestinal lumen exacerbated epithelial damage induced by intestinal <jats:italic>S.\u00a0typhimurium<\/jats:italic> infection at an early stage of the infection. The result suggests that IL\u201017A has a pivotal role in the immediate early stage of protection against bacterial infection at the intestinal mucosa. As IL\u201017A neutralization also suppressed the constitutive localization of \u03b2\u2010defensin 3 (BD3), an IL\u201017A\u2010induced antimicrobial peptide, at the apical site of the intestinal mucosa, it is estimated that IL\u201017A constitutively induces the expression of the antimicrobial peptide to kill invading pathogens at the epithelial surface immediately after the infection. In contrast, interferon\u2010\u03b3 is induced around 3\u2003days after <jats:italic>S.\u00a0typhimurium<\/jats:italic> infection, and its expression level increases thereafter. Taken together, the findings lead to the hypothesis that IL\u201017A participates in the immediate early stage of protection against <jats:italic>S.\u00a0typhimurium<\/jats:italic> intestinal infection whereas interferon\u2010\u03b3 is important at a later stage of the infection.<\/jats:p>","DOI":"10.1111\/j.1365-2567.2010.03310.x","type":"journal-article","created":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T09:36:18Z","timestamp":1277372178000},"page":"377-385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Interleukin\u201017A is required to suppress invasion of <i>Salmonella enterica<\/i> serovar Typhimurium to enteric mucosa"],"prefix":"10.1111","volume":"131","author":[{"given":"Hirokazu","family":"Mayuzumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Inagaki\u2010Ohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Uyttenhove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goro","family":"Matsuzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,24]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1978.tb01700.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-197912000-00001"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.3.1675"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.9.4879-4885.1999"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.1.1-12.2003"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(01)01479-4"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01691-07"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(99)80055-7"},{"key":"e_1_2_8_10_2","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1128\/IAI.66.10.4767-4776.1998","article-title":"Interleukin\u201012 is required for control of the growth of attenuated aromatic\u2010compound\u2010dependent salmonellae in BALB\/c mice: role of \u03b3 interferon and macrophage activation","volume":"66","author":"Mastroeni P","year":"1998","journal-title":"Infect Immun"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.2.1127"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2003.09.019"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-2-200"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00933-08"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1743"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.08.018"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.11.6107"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/422329"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.1.566"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.035"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061308"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636662"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.2.1390"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.062653"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02024-05"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.02841.x"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.5.3456"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2007.tb04008.x"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.03.004"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.06.002"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.9.4432"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.7.4466"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.1.617-621.2005"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080588"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1694"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.03.011"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.5.3482"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00513.2005"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.09.075"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.06.071"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1720"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.11.001"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90135-D"},{"key":"e_1_2_8_44_2","first-page":"42","article-title":"Interaction with extracellular matrix proteins influences Lsh\/Ity\/Bcg (candidate Nramp) gene regulation of macrophage priming\/activation for tumour necrosis factor\u2010\u03b1 and nitrite release","volume":"82","author":"Formica S","year":"1994","journal-title":"Immunology"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031319"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.67.4.457"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2567.2010.03310.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2567.2010.03310.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T09:44:55Z","timestamp":1697363095000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2567.2010.03310.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,24]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1111\/j.1365-2567.2010.03310.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2567.2010.03310.x","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,24]]},"assertion":[{"value":"2010-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}