{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:43:13Z","timestamp":1790080993125,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T00:00:00Z","timestamp":1276560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The active form of vitamin D, 1,25\u2010hydroxyvitamin D<jats:sub>3<\/jats:sub> [1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>] is produced in skin following exposure to sunlight. It is also used topically to control inflammatory skin diseases by stimulating keratinocyte differentiation and suppressing immune responses. Administration of 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> to the skin of mice increases the capacity of CD4<jats:sup>+<\/jats:sup>\u2003CD25<jats:sup>+<\/jats:sup>\u2003(Foxp3<jats:sup>+<\/jats:sup>) regulatory T cells residing in the skin\u2010draining lymph nodes (SDLN) to suppress immune responses. We hypothesized that dendritic cells (DC) may migrate from the skin to the lymph nodes to regulate T\u2010cell function. Increased proportions of skin\u2010derived DC (CD11c<jats:sup>+<\/jats:sup>\u2003ClassII<jats:sup>+<\/jats:sup>\u2003DEC\u2010205<jats:sup>hi<\/jats:sup>\u2003CD8<jats:sup>lo<\/jats:sup>) cells were detected in the SDLN 18\u2003hr after topical 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> treatment of mouse skin. The capacity of DC from the SDLN to take up, process and present antigen to co\u2010cultured T cells was not modified following topical 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>. However, CD11c<jats:sup>+<\/jats:sup> cells from the SDLN of 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>\u2010treated mice induced a significantly smaller ear\u2010swelling response in a T helper type 1\/17\u2010mediated model of contact hypersensitivity. CD4<jats:sup>+<\/jats:sup> CD25<jats:sup>+<\/jats:sup> cells isolated from the ear\u2010draining lymph nodes (EDLN) of mice that received ear injections of CD11c<jats:sup>+<\/jats:sup> cells from donor mice topically treated with 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> more potently suppressed effector cell proliferation. In addition, EDLN cells from recipients of CD11c<jats:sup>+<\/jats:sup> cells from 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>\u2010treated mice produced increased interleukin\u20104 levels. The CD11c<jats:sup>+<\/jats:sup> cells from the SDLN of mice treated with topical 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> expressed increased levels of indoleamine 2,3\u2010dioxygenase messenger RNA, a molecule by which topical 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> may enhance the ability of DC to control the suppressive function of CD4<jats:sup>+<\/jats:sup>\u2003CD25<jats:sup>+<\/jats:sup> cells.<\/jats:p>","DOI":"10.1111\/j.1365-2567.2010.03315.x","type":"journal-article","created":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T13:33:35Z","timestamp":1276608815000},"page":"415-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Topical 1,25\u2010dihydroxyvitamin D<sub>3<\/sub> subverts the priming ability of draining lymph node dendritic 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