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In this study, the ability of interleukin\u20107 (IL\u20107) to enhance memory CD8<jats:sup>+\u2003<\/jats:sup>CD45RA<jats:sup>\u2212\u2003<\/jats:sup>CD127<jats:sup>+<\/jats:sup> T\u2010cell responses in health and in human immunodeficiency virus (HIV) infection was investigated. CD8<jats:sup>+<\/jats:sup> T\u2010cell\u2010depleted peripheral blood mononuclear cells (PBMCs) from HIV<jats:sup>\u2212<\/jats:sup> and untreated HIV<jats:sup>+<\/jats:sup> donors were pulsed with a cytomegalovirus\/Epstein\u2013Barr virus\/influenza (CEF) peptide pool, and co\u2010cultured with autologous memory CD8<jats:sup>+<\/jats:sup> T cells in the presence of IL\u20107. Cell survival and the function of memory CD8<jats:sup>+<\/jats:sup> T\u2010cell subsets were then evaluated. Memory CD8<jats:sup>+<\/jats:sup> T\u2010cell proliferation and interferon\u2010\u03b3 (IFN\u2010\u03b3) production was enhanced by the presence of antigen, and the addition of IL\u20107 further enhanced antigen\u2010induced proliferation. In HIV<jats:sup>+<\/jats:sup> individuals, the presence of antigen enhanced IFN\u2010\u03b3 production to a small degree but did not enhance proliferation. Lastly, IL\u20107 did not enhance antigen\u2010mediated proliferation of memory CD8<jats:sup>+<\/jats:sup> T cells from HIV<jats:sup>+<\/jats:sup> individuals. IL\u20107 therefore appears to have a role in secondary immune responses and its activity is impaired in memory CD8<jats:sup>+<\/jats:sup> T cells from HIV<jats:sup>+<\/jats:sup> individuals. These results further our understanding of the signals involved in secondary immune responses, and provide new insight into the loss of CD8<jats:sup>+<\/jats:sup> T\u2010cell function in HIV infection.<\/jats:p>","DOI":"10.1111\/j.1365-2567.2010.03325.x","type":"journal-article","created":{"date-parts":[[2010,7,28]],"date-time":"2010-07-28T09:53:27Z","timestamp":1280310807000},"page":"525-536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Interleukin\u20107 enhances memory CD8<sup>+<\/sup> T\u2010cell recall responses in health but its activity is impaired in human immunodeficiency virus infection"],"prefix":"10.1111","volume":"131","author":[{"given":"Alison M.","family":"O\u2019Connor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela 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