{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:40:16Z","timestamp":1790516416321,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,7,28]],"date-time":"2010-07-28T00:00:00Z","timestamp":1280275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Replacement therapy with exogenous factor VIII (FVIII) to treat haemorrhages or used in prophylaxis induces inhibitory anti\u2010FVIII immunoglobulin G (IgG) in some patients with haemophilia A. Therapeutic strategies to prevent the onset of the deleterious anti\u2010FVIII immune response are still lacking. Maternal IgG is transferred to the offspring during fetal and neonatal life. While protecting the offspring from bacterial and viral infections, maternal IgG may alter the repertoires of T and B lymphocytes, and may impair vaccination in early infancy. Using haemophilic mice, we demonstrate that the transfer of maternal anti\u2010FVIII IgG modulates the onset of anti\u2010FVIII inhibitory IgG in early adulthood. The protective effect is reproduced upon reconstitution of naive mice with anti\u2010FVIII IgG, suggesting that the reduced ability to mount an anti\u2010FVIII immune response is the result of an interference between circulating anti\u2010FVIII IgG and the administered FVIII rather than to a profound remodelling of lymphocyte repertoires occurring during the ontogeny of the immune system.<\/jats:p>","DOI":"10.1111\/j.1365-2567.2010.03327.x","type":"journal-article","created":{"date-parts":[[2010,7,28]],"date-time":"2010-07-28T09:53:37Z","timestamp":1280310817000},"page":"549-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternally transferred anti\u2010factor VIII IgG reduce the anti\u2010factor VIII humoral immune response in factor VIII\u2010deficient 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