{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:49:03Z","timestamp":1791071343571,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1784,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1111\/j.1365-2567.2010.03351.x","type":"journal-article","created":{"date-parts":[[2010,10,13]],"date-time":"2010-10-13T11:31:42Z","timestamp":1286969502000},"page":"174-187","source":"Crossref","is-referenced-by-count":36,"title":["Rat eosinophils stimulate the expansion of Cryptococcus neoformans-specific CD4+ and CD8+ T cells with a T-helper 1 profile"],"prefix":"10.1111","volume":"132","author":[{"given":"Ana P.","family":"Garro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura S.","family":"Chiapello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"Baronetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana T.","family":"Masih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,13]]},"reference":[{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1128\/IAI.68.7.4225-4237.2000","article-title":"Cryptococcus neoformans is a facultative intracellular pathogen in murine pulmonary infection","volume":"68","author":"Feldmesser","year":"2000","journal-title":"Infect Immun"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1128\/JCM.37.10.3204-3209.1999","article-title":"Epidemiological evidence for dormant Cryptococcus neoformans infection","volume":"37","author":"Garcia-Hermoso","year":"1999","journal-title":"J Clin Microbiol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1128\/IAI.62.11.4755-4761.1994","article-title":"Pathogenesis of pulmonary Cryptococcus neoformans infection in the rat","volume":"62","author":"Goldman","year":"1994","journal-title":"Infect Immun"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1084\/jem.173.4.793","article-title":"Immunity to a pulmonary Cryptococcus neoformans infection requires both CD4+ and CD8+ T cells","volume":"173","author":"Huffnagle","year":"1991","journal-title":"J Exp Med"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"4529","DOI":"10.4049\/jimmunol.157.10.4529","article-title":"Afferent phase production of TNF\u03b1 is required for the development of protective T cell immunity to Cryptococcus neoformans","volume":"157","author":"Huffnagle","year":"1996","journal-title":"J Immunol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1006\/clim.1998.4639","article-title":"Involvement of nitric oxide in protecting mechanism during experimental cryptococcosis","volume":"90","author":"Rossi","year":"1999","journal-title":"Clin Immunol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/02681219480000561","article-title":"Biochemical basis for the killing of Cryptococcus neoformans by rat peritoneal cells","volume":"32","author":"Rossi","year":"1994","journal-title":"J Med Vet Mycol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.molbiopara.2008.10.005","article-title":"Involvement of a mitochondrial pathway and key role of hydrogen peroxide during eosinophil apoptosis induced by excretory-secretory products from Fasciola hepatica","volume":"163","author":"Serradell","year":"2009","journal-title":"Mol Biochem Parasitol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.immunol.24.021605.090720","article-title":"The eosinophil","volume":"24","author":"Rothenberg","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.4049\/jimmunol.167.6.3146","article-title":"Eosinophils promote allergic disease of the lung by regulating CD4+ Th2 lymphocyte function","volume":"167","author":"MacKenzie","year":"2001","journal-title":"J Immunol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB11|cit11","first-page":"6","article-title":"Effects of antigen presentation of eosinophils on lung Th1\/Th2 imbalance","volume":"118","author":"Xie","year":"2005","journal-title":"Chin Med J"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1046\/j.1398-9995.2003.00405.x","article-title":"Endobronchial eosinophils preferentially stimulate T helper cell type 2 responses","volume":"59","author":"Shi","year":"2004","journal-title":"Allergy"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1128\/IAI.02067-05","article-title":"Eosinophils can function as antigen-presenting cells to induce primary and secondary immune responses to Strongyloides stercoralis","volume":"74","author":"Padigel","year":"2006","journal-title":"Infect Immun"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB14|cit14","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1086\/522968","article-title":"Eosinophils act as antigen-presenting cells to induce immunity to Strongyloides stercoralis in mice","volume":"196","author":"Padigel","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1172\/JCI8945","article-title":"Lymph node trafficking and antigen presentation by endobronchial eosinophils","volume":"105","author":"Shi","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1189\/jlb.0404228","article-title":"Eosinophils function as antigen-presenting cells","volume":"76","author":"Shi","year":"2004","journal-title":"J Leukoc Biol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1001\/archinte.148.4.895","article-title":"Eosinophilia in coccidioidomycosis","volume":"148","author":"Schermoly","year":"1988","journal-title":"Arch Intern Med"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4269\/ajtmh.1998.59.66","article-title":"Localization of eosinophil granule major basic protein in paracoccidioidomycosis lesions","volume":"59","author":"Wagner","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1128\/IAI.65.5.1899-1907.1997","article-title":"Eosinophils-Cryptococcus neoformans interactions in vivo and in vitro","volume":"65","author":"Feldmesser","year":"1997","journal-title":"Infect Immun"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1006\/clim.2001.5046","article-title":"Mechanisms for induction of immunosuppression during experimental cryptococcosis. Role of glucuronoxylomannan","volume":"100","author":"Chiapello","year":"2001","journal-title":"Clin Immunol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/1369378031000137260","article-title":"Apoptosis induction by glucuronoxylomannan of Cryptococcus neoformans","volume":"41","author":"Chiapello","year":"2003","journal-title":"Med Mycol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1365-2567.2004.01970.x","article-title":"Immunosuppression, interleukin-10 synthesis and apoptosis are induced in rats inoculated with Cryptococcus neoformans glucuronoxylomannan","volume":"113","author":"Chiapello","year":"2004","journal-title":"Immunology"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1093\/intimm\/dxn112","article-title":"Cryptococcus neoformans glucuronoxylomannan induces macrophage apoptosis mediated by nitric oxide in a caspase-independent pathway","volume":"20","author":"Chiapello","year":"2008","journal-title":"Int Immunol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0022-1759(96)00139-1","article-title":"Effect of isolation protocol on eosinophil function: Percoll gradients versus immunomagnetic beads","volume":"198","author":"Sedgwick","year":"1996","journal-title":"J Immunol Methods"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1074-7613(02)00328-X","article-title":"CR3 (CD11b\/CD18) and CR4 (CD11c\/CD18) are involved in complement-independent antibody-mediated phagocytosis of Cryptococcus neoformans","volume":"16","author":"Taborda","year":"2002","journal-title":"Immunity"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"40161","DOI":"10.1074\/jbc.M401370200","article-title":"Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization","volume":"279","author":"Chaturvedi","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1002\/eji.1830220736","article-title":"Eosinophil as antigen-presenting cell: activation of T cell clones and T cell hybridoma by eosinophils after antigen processing","volume":"22","author":"Del","year":"1992","journal-title":"Eur J Immunol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF00915359","article-title":"Functional heterogeneity of human antigen-presenting cells: presentation of soluble antigen but not self-Ia by monocytes","volume":"6","author":"Moreno","year":"1986","journal-title":"J Clin Immunol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/13693780600750022","article-title":"Heat killed cells of Cryptococcus neoformans var. grubii induce protective immunity in rats: immunological and histopathological parameters","volume":"44","author":"Baronetti","year":"2006","journal-title":"Med Mycol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1128\/IAI.66.2.664-669.1998","article-title":"Encapsulation of Cryptococcus neoformans with Glucuronoxylomannan inhibits the antigen-presenting capacity of monocytes","volume":"66","author":"Retini","year":"1998","journal-title":"Infect Immun"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"5972","DOI":"10.1128\/IAI.70.11.5972-5981.2002","article-title":"Primary dendritic cells phagocytose Cryptococcus neoformans via mannose receptor and Fc\u03b3 receptor II for presentation to T lymphocytes","volume":"70","author":"Syme","year":"2002","journal-title":"Infect Immun"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1086\/426511","article-title":"Glucuronoxylomannan, a microbial compound, regulates expresion of costimulatory molecules and cytokine production in macrophages","volume":"191","author":"Monari","year":"2005","journal-title":"J Infect Dis"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1084\/jem.184.5.1871","article-title":"Schistosoma mansoni egg induced early IL-4 production is dependent upon IL-5 and eosinophils","volume":"184","author":"Sabin","year":"1996","journal-title":"J Exp Med"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1126\/science.1099472","article-title":"Defining a link with asthma in mice congenitally deficient in eosinophils","volume":"305","author":"Lee","year":"2004","journal-title":"Science"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.2353\/ajpath.2007.060595","article-title":"Role of granulocyte macrophage colony-stimulating factor in host defense against pulmonary Cryptococcus neoformans infection during murine allergic bronchopulmonary mycosis","volume":"170","author":"Chen","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.immunol.17.1.593","article-title":"Mechanisms of phagocytosis in macrophages","volume":"17","author":"Aderem","year":"1999","journal-title":"Annu Rev Immunol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB37|cit37","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1002\/jlb.66.5.712","article-title":"Modular components of phagocytosis","volume":"66","author":"Greenberg","year":"1999","journal-title":"J Leukoc Biol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB38|cit38","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1600-0463.2008.00022.x","article-title":"Phagocytosis of heat-killed Staphylococcus aureus by eosinophils: comparison with neutrophils","volume":"117","author":"Hatano","year":"2009","journal-title":"APMIS"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB39|cit39","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1182\/blood-2007-01-071340","article-title":"Eosinophils contribute to innate immunity and promote clearance of respiratory syncytial virus","volume":"110","author":"Phipps","year":"2007","journal-title":"Blood"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB40|cit40","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/mmy.38.5.343.353","article-title":"Differing requirement for inducible nitric oxide synthase activity in clearance of primary and secondary Cryptococcus neoformans infection","volume":"38","author":"Aguirre","year":"2000","journal-title":"Med Mycol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB41|cit41","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.4049\/jimmunol.177.8.5509","article-title":"In the absence of reactive oxygen species, T cells default to a Th1 phenotype and mediate protection against pulmonary Cryptococcus neoformans infection","volume":"177","author":"Snelgrove","year":"2006","journal-title":"J Immunol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB42|cit42","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/cimm.1997.1166","article-title":"Cryptococcus neoformans inhibits nitric oxide production by murine peritoneal macrophages stimulated with interferon-\u03b3 and lipopolysaccharide","volume":"180","author":"Kawakami","year":"1997","journal-title":"Cell Immunol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB43|cit43","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/jlb.55.1.35","article-title":"The role of CD4+ and CD8+ T cells in the protective inflammatory response to a pulmonary cryptococcal infection","volume":"55","author":"Huffnagle","year":"1994","journal-title":"J Leukoc Biol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB44|cit44","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.4049\/jimmunol.160.3.1279","article-title":"Eosinophils bind rhinovirus and activate virus-specific T cells","volume":"160","author":"Handzel","year":"1998","journal-title":"J Immunol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB45|cit45","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jaci.2008.03.028","article-title":"Virus-induced eosinophil mediator release requires antigen presenting and CD4+ T cells","volume":"122","author":"Davoine","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB46|cit46","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cellimm.2003.09.008","article-title":"Accelerated antigen presentation and elicitation of humoral response in vivo by Fc\u03b3RIIB- and Fc\u03b3RI\/III-mediated immune complex uptake","volume":"225","author":"Yada","year":"2003","journal-title":"Cell Immunol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB47|cit47","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0966-842X(01)02035-2","article-title":"Intracellular parasitism of macrophages by Cryptococcus neoformans","volume":"9","author":"Feldmesser","year":"2001","journal-title":"Trends Microbiol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB48|cit48","doi-asserted-by":"crossref","first-page":"7920","DOI":"10.4049\/jimmunol.174.12.7920","article-title":"Generation of antifungal effector CD8+ T cells in the absence of CD4+ T cells during Cryptococcus neoformans infection","volume":"174","author":"Lindell","year":"2005","journal-title":"J Immunol"},{"key":"10.1111\/j.1365-2567.2010.03351.x-BIB49|cit49","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.4049\/jimmunol.152.8.3970","article-title":"CD8 cells play a critical role in delayed type hypersensitivity to intact Crypfococcus neoformans","volume":"152","author":"Mody","year":"1994","journal-title":"J Immunol"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2567.2010.03351.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1365-2567.2010.03351.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T20:02:15Z","timestamp":1685822535000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2567.2010.03351.x"}},"subtitle":["Eosinophil as C.\u00a0neoformans antigen-presenting cell"],"short-title":[],"issued":{"date-parts":[[2010,10,13]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2567.2010.03351.x","relation":{},"ISSN":["0019-2805"],"issn-type":[{"value":"0019-2805","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10,13]]}}}