{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:07:03Z","timestamp":1793045223532,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,2]],"date-time":"2012-03-02T00:00:00Z","timestamp":1330646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Diabetes mellitus is a predisposing factor of melioidosis, contributing to higher mortality rates in diabetics infected with\n                    <jats:italic>Burkholderia pseudomallei<\/jats:italic>\n                    . To investigate how diabetes alters the inflammatory response, we established a streptozotocin (STZ) \u2010induced diabetic murine acute\u2010phase melioidosis model. Viable\n                    <jats:italic>B.\u00a0pseudomallei<\/jats:italic>\n                    cells were consistently detected in the blood, liver and spleen during the 42\u2010hr course of infection but the hyperglycaemic environment did not increase the bacterial burden. However, after 24\u2003hr, granulocyte counts increased in response to infection, whereas blood glucose concentrations decreased over the course of infection. A genome\u2010wide expression analysis of the STZ\u2010diabetic murine acute melioidosis liver identified \u223c\u20031000 genes whose expression was altered in the STZ\u2010diabetic mice. The STZ\u2010diabetic host transcriptional response was compared with the normoglycaemic host transcriptional response recently reported by our group. The microarray data suggest that the presence of elevated glucose levels impairs the host innate immune system by delaying the identification and recognition of\n                    <jats:italic>B.\u00a0pseudomallei<\/jats:italic>\n                    surface structures. Consequently, the host is unable to activate the appropriate innate immune response over time, which may explain the increased susceptibility to melioidosis in the STZ\u2010diabetic host. Nevertheless, a general \u2018alarm signal\u2019 of infection as well as defence programmes are still triggered by the STZ\u2010diabetic host, although only 24\u2003hr after infection. In summary, this study demonstrates that in the face of a\n                    <jats:italic>B.\u00a0pseudomallei<\/jats:italic>\n                    acute infection, poor glycaemic control impaired innate responses during the early stages of\n                    <jats:italic>B.\u00a0pseudomallei<\/jats:italic>\n                    infection, contributing to the increased susceptibility of STZ\u2010induced diabetics to this fatal disease.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2567.2011.03544.x","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T18:10:43Z","timestamp":1322935843000},"page":"312-332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Delayed activation of host innate immune pathways in streptozotocin\u2010induced diabetic hosts leads to more severe disease during infection with\n                    <i>Burkholderia pseudomallei<\/i>"],"prefix":"10.1111","volume":"135","author":[{"given":"Chui\u2010Yoke","family":"Chin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise M.","family":"Monack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Nathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,2]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq576"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22711.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400406"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1999.tb01397.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.qco.0000244046.31135.b3"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.2.383-416.2005"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/414813a"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.61.10.4045-4050.1993"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.53.2.159"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/367861"},{"key":"e_1_2_7_12_2","first-page":"63","article-title":"Reduced interleukin\u201017 expression of Burkholderia pseudomallei\u2010infected peripheral blood mononuclear cells of diabetic patients","volume":"26","author":"Pongcharoen S","year":"2008","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00503-08"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02677.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.2741\/2757"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2007.01.002"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.6.2891-2900.1999"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0478OC"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-672"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.2.504-511.2002"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(01)01417-4"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1104.041051"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2008.069617"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2008.069609"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-181"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-48-6-535"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040248"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(08)70021-X"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902113400607"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1086\/497382"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq192"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2007.05.012"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1999.00657.x"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03212.x"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2006005000143"},{"key":"e_1_2_7_36_2","first-page":"187","article-title":"Impaired immune responses in diabetes mellitus: analysis of the factors and mechanisms involved. 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