{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T11:48:13Z","timestamp":1759664893033},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,2]],"date-time":"2012-03-02T00:00:00Z","timestamp":1330646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Deficiency in <jats:italic>Daf1<\/jats:italic>, a complement regulatory protein, has been shown to exacerbate development of various autoimmune diseases and recent studies have suggested that this may be explained by <jats:italic>Daf1<\/jats:italic> acting to limit T\u2010cell hyper\u2010responsiveness. It has been suggested that the absence of <jats:italic>Daf1<\/jats:italic> aggravates autoimmune disease in a complement\u2010dependent manner, but others have shown that activation of T cells in the absence of <jats:italic>Daf1<\/jats:italic> can be complement independent. However, the relationship between Daf1, complement components, lymphocyte activation, cytokine expression and antibody production remains to be determined in mice that are not <jats:italic>Daf1<\/jats:italic> deficient. We have recently demonstrated, in murine mercury\u2010induced autoimmunity (mHgIA), that an accumulation of CD44<jats:sup>high<\/jats:sup> Daf<jats:sup>low<\/jats:sup>\u2003CD4<jats:sup>+<\/jats:sup> T cells is associated with the development of autoimmunity. In this study we observed that complement depletion does not affect the accumulation of activated CD4<jats:sup>+<\/jats:sup> T cells, elevation of splenic interleukin\u20104 expression and autoantibody production in mHgIA. In addition, neither the accumulation of CD44<jats:sup>high<\/jats:sup>\u2003Daf<jats:sup>low<\/jats:sup>\u2003CD4<jats:sup>+<\/jats:sup> T cells nor the down\u2010regulation of <jats:italic>Daf1<\/jats:italic> expression on CD4<jats:sup>+<\/jats:sup> T cells was influenced by a lack of complement. In conclusion, these studies show that initiating events in xenobiotic\u2010induced autoimmunity, including lymphocyte activation, cytokine expression and autoantibody production, are not dependent on complement.<\/jats:p>","DOI":"10.1111\/j.1365-2567.2011.03545.x","type":"journal-article","created":{"date-parts":[[2011,12,5]],"date-time":"2011-12-05T10:02:08Z","timestamp":1323079328000},"page":"333-343","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Depletion of complement does not impact initiation of xenobiotic\u2010induced autoimmune disease"],"prefix":"10.1111","volume":"135","author":[{"given":"David M.","family":"Cauvi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher B.","family":"Toomey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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