{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:06:39Z","timestamp":1792663599684,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,8,2]],"date-time":"2012-08-02T00:00:00Z","timestamp":1343865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Natural killer (<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>) cells have a specialized function in peripheral organs, which is determined by the organ\u2010specific niches. We have attempted to explore whether lung <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells display a particular phenotype according to their function in the unique pulmonary environment in health or during respiratory infection in mice. In healthy mice, higher frequencies of <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells among lymphocytes were detected in the lung than in other tissues (lymph node, bone marrow, spleen, blood and liver), and lung <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells maintained a more mature phenotype, implying that lung <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells were critical for the pulmonary immune response. However, lung <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells expressed higher levels of inhibitory receptors and lower levels of activating receptors, migration\/adhesion\u2010associated molecules and co\u2010stimulatory molecules than splenic <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells, implying that lung <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells were quiescent, and the activation of lung <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells was tightly regulated by the pulmonary environment in health. During respiratory infection, lung <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells could be activated and express functional molecules (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>107a and interferon\u2010\u03b3) to take part in the response to infection quickly. These results suggested that the unique pulmonary environment promotes the development of <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells with a lung\u2010specific phenotype.<\/jats:p>","DOI":"10.1111\/j.1365-2567.2012.03607.x","type":"journal-article","created":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T11:35:32Z","timestamp":1337686532000},"page":"37-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["Lung natural killer cells in mice: phenotype and response to respiratory infection"],"prefix":"10.1111","volume":"137","author":[{"given":"Jian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Immunology School of Life Sciences University of Science and Technology of China Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Life Sciences University of Science and Technology of China Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Life Sciences University of Science and Technology of China Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Life Sciences University of Science and Technology of China Hefei Anhui China"},{"name":"Hefei National Laboratory for Physical Sciences at Microscale Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Life Sciences University of Science and Technology of China Hefei Anhui China"},{"name":"Hefei National Laboratory for Physical Sciences at Microscale Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Life Sciences University of Science and Technology of China Hefei Anhui China"},{"name":"Hefei National Laboratory for Physical Sciences at Microscale Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2154"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200106)31:6<1900::AID-IMMU1900>3.0.CO;2-M"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1582"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2007.00563.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03167.x"},{"key":"e_1_2_6_7_1","first-page":"100","article-title":"Locally and systemically derived natural killer cells participate in defense against intranasally inoculated influenza virus","volume":"1","author":"Stein\u2010Streilein J","year":"1988","journal-title":"Reg Immunol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18125"},{"key":"e_1_2_6_9_1","first-page":"437","article-title":"Natural cytotoxic activity in human lungs","volume":"47","author":"Bordignon C","year":"1982","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(86)90073-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2236"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90625.2008"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.08.015"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.12.7658-7663.2005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.4049\/jimmunol.131.6.2699","article-title":"Natural killer cells in mouse lung: surface phenotype, target preference, and response to local influenza virus infection","volume":"131","author":"Stein\u2010Streilein J","year":"1983","journal-title":"J Immunol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00454.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-187179"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2006.05.002"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri956"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1138"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838882"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.4049\/jimmunol.161.1.400","article-title":"Differential expression and function of L\u2010selectin on CD56bright and CD56dim natural killer cell subsets","volume":"161","author":"Frey M","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115628"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000081309"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111513"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2009.01.005"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1081\/CNV-120001185"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21158"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22725"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06209-11"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2567.2012.03607.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2567.2012.03607.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T06:28:04Z","timestamp":1698647284000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2567.2012.03607.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,2]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1365-2567.2012.03607.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2567.2012.03607.x","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,2]]},"assertion":[{"value":"2011-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-08-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}