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This suggests that ferritin may serve as a cytotoxic protector against the oxidative challenge of the blood meal and may be essential for the survival of the insect. In this study, various\n                    <jats:italic>cis<\/jats:italic>\n                    \u2010acting elements for the gene were identified and mapped. Transfection assays showed that the strength and activity of a subset of these elements are orientation\u2010dependent. The shift observed for the\n                    <jats:italic>ferritin HCH cis<\/jats:italic>\n                    \u2010acting elements is unique among known\n                    <jats:italic>ferritin<\/jats:italic>\n                    genes. DNase I footprinting data together with\n                    <jats:italic>Transfac<\/jats:italic>\n                    analyses identified a number of putative sites known for their involvement in developmental and cell proliferation processes.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2583.2004.00550.x","type":"journal-article","created":{"date-parts":[[2005,6,19]],"date-time":"2005-06-19T15:58:16Z","timestamp":1119196696000},"page":"223-236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Regulation of the\n                    <i>ferritin heavy\u2010chain homologue<\/i>\n                    gene in the yellow fever mosquito,\n                    <i>Aedes aegypti<\/i>"],"prefix":"10.1111","volume":"14","author":[{"given":"D. Q.\u2010D.","family":"Pham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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