{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:50:19Z","timestamp":1791143419953,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T00:00:00Z","timestamp":1117497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["resjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Insect Molecular Biology"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The effect of gene expression knockdown was used to study the function of the sterol carrier protein\u20102 (AeSCP\u20102) in the yellow fever mosquito,\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    . Injection of small double stranded AeSCP\u20102 RNAs into mosquito larvae resulted in the knockdown of gene products. The lack of AeSCP\u20102 in larvae coincided with a reduction in accumulated cholesterol in pupae, supporting the hypothesis that AeSCP\u20102 may be involved in cholesterol uptake in mosquito larvae. Knockdown of AeSCP\u20102 caused a high mortality rate in developing adult and reduced egg viability. Results from this study indicate that AeSCP\u20102 is important for adult development and for the viability of the eggs.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2583.2005.00560.x","type":"journal-article","created":{"date-parts":[[2005,6,19]],"date-time":"2005-06-19T15:58:16Z","timestamp":1119196696000},"page":"301-307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Functional analysis of AeSCP\u20102 using gene expression knockdown in the yellow fever mosquito,\n                    <i>Aedes aegypti<\/i>"],"prefix":"10.1111","volume":"14","author":[{"given":"E. 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