{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:42:57Z","timestamp":1779338577557,"version":"3.51.4"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,6,24]],"date-time":"2011-06-24T00:00:00Z","timestamp":1308873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["resjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Insect Molecular Biology"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The oxysterol\u2010binding protein (OSBP) and OSBP\u2010related proteins (ORPs) are sterol\u2010binding proteins that may be involved in cellular sterol transportation, sterol metabolism and signal transduction pathways. Four ORP genes were cloned from\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    . Based on amino acid sequence homology to human proteins, they are\n                    <jats:italic>AeOSBP<\/jats:italic>\n                    ,\n                    <jats:italic>AeORP1<\/jats:italic>\n                    ,\n                    <jats:italic>AeORP8<\/jats:italic>\n                    and\n                    <jats:italic>AeORP9<\/jats:italic>\n                    . Splicing variants of\n                    <jats:italic>AeOSBP<\/jats:italic>\n                    and\n                    <jats:italic>AeORP8<\/jats:italic>\n                    were identified. The temporal and spatial transcription patterns of members of the AeOSBP gene family through developmental stages and the gonotrophic cycle were profiled.\n                    <jats:italic>AeORP1<\/jats:italic>\n                    transcription seemed to be head tissue\u2010specific, whereas\n                    <jats:italic>AeOSBP<\/jats:italic>\n                    and\n                    <jats:italic>AeORP9<\/jats:italic>\n                    expression was induced by a bloodmeal. Furthermore, over\u2010expression of AeORPs facilitated [\n                    <jats:sup>3<\/jats:sup>\n                    H]\u2010cholesterol uptake in\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    cultured\n                    <jats:italic>Aag \u20102<\/jats:italic>\n                    cells.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2583.2011.01087.x","type":"journal-article","created":{"date-parts":[[2011,6,25]],"date-time":"2011-06-25T18:47:27Z","timestamp":1309027647000},"page":"541-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Characterization of the oxysterol\u2010binding protein gene family in the yellow fever mosquito,\n                    <i>Aedes aegypti<\/i>"],"prefix":"10.1111","volume":"20","author":[{"given":"Q.","family":"Fu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lynn\u2010Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,6,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(97)00159-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/157.3.1117"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2806(03)31001-X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2583.2005.00560.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.21.1.23"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.22.010305.104656"},{"key":"e_1_2_6_8_1","volume-title":"Aedes 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