{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T07:14:37Z","timestamp":1766733277015},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,12,13]],"date-time":"2004-12-13T00:00:00Z","timestamp":1102896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> To evaluate the effect of capsaicin on substance P (SP) expression during induced inflammation in rat pulp tissue.<\/jats:p><jats:p><jats:bold>Methodology\u2002<\/jats:bold> Radioimmunoanalysis was used to measure SP levels in 36 mandibular molar pulps taken from six Wistar rats. Twelve samples were obtained from healthy pulps and used as negative control group. Another 12 samples were obtained after inducing inflammation with mechanical pulp exposure; these were used as the positive control group. Capsaicin was infiltrated into the inferior dental nerve in the experimental group and 12 samples were obtained after mechanical pulp exposure.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The lowest SP expression was found in mechanically exposed pulps where capsaicin pretreatment had been carried out (0.028\u2003ng\u2003mL<jats:sup>\u22121<\/jats:sup>), followed by healthy pulps (0.302\u2003ng\u2003mL<jats:sup>\u22121<\/jats:sup>). The highest SP expression was found in mechanically exposed pulps with no capsaicin pretreatment (124\u2003ng\u2003mL<jats:sup>\u22121<\/jats:sup>). The Kruskal\u2013Wallis test showed statistically significant differences between the groups (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Inferior dental nerve infiltration with capsaicin reduces SP expression in dental pulp tissue in rats.<\/jats:p>","DOI":"10.1111\/j.1365-2591.2004.00893.x","type":"journal-article","created":{"date-parts":[[2004,12,13]],"date-time":"2004-12-13T12:18:05Z","timestamp":1102940285000},"page":"30-33","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The effect of capsaicin on substance P expression in pulp tissue inflammation"],"prefix":"10.1111","volume":"38","author":[{"given":"J.","family":"Caviedes\u2010Bucheli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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R.","family":"Munoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,12,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2002.00451.x"},{"key":"e_1_2_10_3_1","first-page":"179","article-title":"The neuropharmacology of capsaicin: review of some recent observations","volume":"38","author":"Buck SH","year":"1986","journal-title":"Pharmacological Reviews"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1995.tb44703.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)81213-6"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(94)90045-0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200306000-00004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411990100030501"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-05-01716.1992"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00427-9"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345970760070301"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(96)00092-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)81563-3"},{"key":"e_1_2_10_14_1","first-page":"229","article-title":"Temporomandibular joint nociception: effects of capsaicin on substance P\u2010like immunoreactivity in the rabbit brain stem","volume":"16","author":"Kyrkanides S","year":"2002","journal-title":"Journal of Orofacial Pain"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(94)90188-0"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.40.020189.002013"},{"key":"e_1_2_10_17_1","first-page":"85","article-title":"Substance P","volume":"35","author":"Pernow B","year":"1983","journal-title":"Pharmacological Reviews"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.82.116"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2591.2004.00893.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2591.2004.00893.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T04:24:33Z","timestamp":1697171073000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2591.2004.00893.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,13]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1111\/j.1365-2591.2004.00893.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2591.2004.00893.x","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,13]]},"assertion":[{"value":"2004-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}