{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:36:37Z","timestamp":1758267397425},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,5,5]],"date-time":"2005-05-05T00:00:00Z","timestamp":1115251200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> To compare tissue\u2010type plasminogen activator (t\u2010PA) expression in normal human pulp and inflamed human pulp tissue specimens.<\/jats:p><jats:p><jats:bold>Methodology\u2002<\/jats:bold> Thirty pulpal tissue specimens (13 normal and 17 inflamed pulps) were obtained from extracted third molars. The levels of t\u2010PA between normal pulp and inflamed pulp tissues were compared using the quantitative reverse\u2010transcriptase polymerase chain reaction analysis. In addition, immunohistochemistry was used to identify the <jats:italic>in situ<\/jats:italic> localization of t\u2010PA expression in pulp specimens. Wilcoxon\u2013Mann\u2013Whitney rank sum test was applied for the statistical analysis of the results.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> t\u2010PA mRNA gene was found more in inflamed pulps when compared with normal pulp tissue (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). The results from immunohistochemistry demonstrated that t\u2010PA expression was significantly higher in the inflamed pulp (<jats:italic>P<\/jats:italic>\u2003=\u20030.025). t\u2010PA stain was detected in the fibroblasts, inflammatory infiltrates and endothelial cells.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> t\u2010PA expression was significantly higher in inflamed pulp tissue. t\u2010PA may play an important role in the pathogenesis of pulpal inflammation.<\/jats:p>","DOI":"10.1111\/j.1365-2591.2005.00951.x","type":"journal-article","created":{"date-parts":[[2005,5,5]],"date-time":"2005-05-05T15:07:50Z","timestamp":1115305670000},"page":"328-333","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Upregulation of tissue\u2010type plasminogen activator in inflamed human dental 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