{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:16:49Z","timestamp":1790702209264,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,9,12]],"date-time":"2005-09-12T00:00:00Z","timestamp":1126483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> To use radioreceptor analysis for comparing calcitonin gene\u2010related peptide (CGRP) receptor expression in human pulp tissue samples collected from teeth having a clinical diagnosis of acute irreversible pulpitis, healthy pulps and teeth with induced inflammation.<\/jats:p><jats:p><jats:bold>Methodology\u2002<\/jats:bold> Six pulp samples were obtained from teeth having a clinical diagnosis of acute irreversible pulpitis. Another eight pulp samples were obtained from healthy premolars where extraction was indicated for orthodontic purposes. In four of these premolars, inflammation was induced prior to pulp collection. All the samples were processed and labelled with <jats:sup>125<\/jats:sup>I\u2010CGRP. Binding sites were identified by <jats:sup>125<\/jats:sup>I\u2010CGRP and standard CGRP competition assays.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> CGRP receptor expression was found in all human pulp tissue samples. Most receptors were found in the group of pulps from teeth having a clinical diagnosis of acute irreversible pulpitis, followed by the group of pulps having induced inflammation. The least number of receptors was expressed in the group of healthy pulps. The Kruskal\u2013Wallis and Mann\u2013Whitney (<jats:italic>post\u2010hoc<\/jats:italic>) tests showed statistically significant differences between the groups (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> CGRP receptor expression in human pulp tissue is significantly increased during inflammatory phenomena such as acute irreversible pulpitis.<\/jats:p>","DOI":"10.1111\/j.1365-2591.2005.01006.x","type":"journal-article","created":{"date-parts":[[2005,9,12]],"date-time":"2005-09-12T16:37:54Z","timestamp":1126543074000},"page":"712-717","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Calcitonin gene\u2010related peptide receptor expression in healthy and inflamed human pulp tissue"],"prefix":"10.1111","volume":"38","author":[{"given":"J.","family":"Caviedes\u2010Bucheli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Arenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Guiza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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