{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:08:27Z","timestamp":1791482907161,"version":"4.3.4"},"reference-count":157,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,3,13]],"date-time":"2006-03-13T00:00:00Z","timestamp":1142208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bacterial sampling of prepared root canals is used to determine the presence and character of the remaining microbiota. However, it is likely that current sampling techniques only identify organisms in the main branches of the root canal system whereas it is unlikely that they can sample areas beyond the apical end\u2010point of preparation and filling, or in lateral canals, canal extensions, apical ramifications, isthmuses and within dentinal tubules. Thus, it may be impossible by current techniques to identify residual post\u2010treatment root canal infection. In histologic observations of root apices, bacteria have been found in inaccessible inter\u2010canal isthmuses and accessory canals often in the form of biofilms. There is no <jats:italic>in vivo<\/jats:italic> evidence to support the assumption that these bacteria can be entombed effectively in the canal system by the root filling and thus be rendered harmless. As a consequence of this residual root infection, post\u2010treatment apical periodontitis, which may be radiographically undetectable, may persist or develop as a defence mechanism to prevent the systemic spread of bacteria and\/or their byproducts to other sites of the body. Histologic observation of root apices with surrounding bone removed from either patients or human cadavers has demonstrated that post\u2010treatment apical periodontitis is associated with 50\u201390% of root filled human teeth. Thus, if the objective of root canal treatment is to eliminate apical periodontitis at a histological level, current treatment procedures are inadequate. It is essential that our knowledge of the local and systemic consequences of both residual post\u2010treatment root infection and post\u2010treatment apical periodontitis be improved. The continued development of treatments that can effectively eliminate root infection is therefore a priority in clinical endodontic research. Post\u2010treatment disease following root canal treatment is most often associated with poor quality procedures that do not remove intra\u2010canal infection; this scenario can be corrected via a nonsurgical approach. However, infection remaining in the inaccessible apical areas, extraradicular infection including apically extruded dentine debris with bacteria present in dentinal tubules, true radicular cysts, and foreign body reactions require a surgical intervention.<\/jats:p>","DOI":"10.1111\/j.1365-2591.2006.01092.x","type":"journal-article","created":{"date-parts":[[2006,3,13]],"date-time":"2006-03-13T16:10:37Z","timestamp":1142266237000},"page":"343-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":181,"title":["Consequences of and strategies to deal with residual post\u2010treatment root canal infection"],"prefix":"10.1111","volume":"39","author":[{"given":"M.\u2010K.","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M. H.","family":"Dummer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. R.","family":"Wesselink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1990.tb00798.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2003.00689.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(83)80030-2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200402000-00003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)81989-8"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(82)80212-4"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1961.0030"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130401500204"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(79)80080-1"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2003.00650.x"},{"issue":"11","key":"e_1_2_11_12_1","first-page":"1","article-title":"A histological and roentgenological study of periapical region of human upper incisors","volume":"18","author":"Brynolf I","year":"1967","journal-title":"Odontologisk Revy"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2000.00384.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.don.0000158008.34623.6c"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1987.tb00543.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(97)80191-4"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1546.2004.00087.x"},{"key":"e_1_2_11_18_1","article-title":"Lesions of endodontic origin and risk of coronary heart disease","volume":"83","author":"Caplan DJ","year":"2004","journal-title":"Journal of Dental Research"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200211000-00008"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.1997.00089.x"},{"key":"e_1_2_11_21_1","first-page":"131","article-title":"Endodontic failures \u2013 changing the approach","volume":"46","author":"Cheung GSP","year":"1996","journal-title":"International Dental Journal"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-5712(03)00032-0"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1318"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(87)90104-1"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(82)90105-0"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(82)90223-7"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2000.00295.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1998.3.1.281"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.306.6879.688"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2003.00640.x"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1984.tb00404.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)80684-9"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(77)90309-7"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1991.tb00434.x"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2001.00398.x"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-1546.2002.10105.x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350310005510"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(96)80221-4"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(85)80180-1"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200401000-00001"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(97)90324-3"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(74)90293-X"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660081801"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1546.2003.00041.x"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2004.00828.x"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2002.00538.x"},{"key":"e_1_2_11_47_1","first-page":"364","article-title":"Treatment outcome of surgical and non\u2010surgical management of endodontic failures","volume":"63","author":"Hepworth MJ","year":"1997","journal-title":"Journal of Canadian Dental Association"},{"key":"e_1_2_11_48_1","volume-title":"The Anatomy of the Root Canals of the Teeth of the Permanent and Deciduous Dentitions","author":"Hess W","year":"1925"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345920710030901"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2000.00303.x"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2001.00431.x"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-7325.2004.tb02755.x"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-1546.2002.10102.x"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2003.107"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345960750090301"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)81173-8"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2001.00436.x"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1955.0099"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2004.00848.x"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(94)90153-8"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(97)80296-8"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200212000-00006"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.4.547-558.2000"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.10.1528"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(79)90279-2"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1992.tb01154.x"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345930720080901"},{"key":"e_1_2_11_68_1","first-page":"51","article-title":"Dental infections as a risk factor for acute myocardial infarction","volume":"14","author":"Mattila KJ","year":"1993","journal-title":"European Heart Journal"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6676.779"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(93)90263-T"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.3.588"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790020901"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2003.08.017"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.1998.t01-1-00111.x"},{"key":"e_1_2_11_75_1","first-page":"475","article-title":"Influence on periapical tissues of indigenous oral bacteria and necrotic pulp tissue in monkeys","volume":"89","author":"M\u00f6ller AJR","year":"1981","journal-title":"Scandinavian Journal of Dental Research"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0143-2885.2001.00525.x"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2000.00293.x"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(87)80089-4"},{"key":"e_1_2_11_79_1","first-page":"68","volume-title":"Essential Endodontology","author":"Nair PNR","year":"1998"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130401500604"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(07)80202-0"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(07)80202-0"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1993.tb00563.x"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0909-8836.1998.eos106206.x"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(99)70145-9"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.10.005"},{"key":"e_1_2_11_87_1","first-page":"1","volume-title":"Essential Endodontology","author":"\u00d8rstavik D","year":"1998"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1987.tb00621.x"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2004.00122.x"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1995.tb00166.x"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200102000-00002"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0143-2885.2001.00447.x"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2003.00628.x"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(72)90214-9"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1995.tb00150.x"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.1998.00170.x"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2003.00721.x"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.1998.00183.x"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704033361401"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003233421202"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2481"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(76)90131-6"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1974.tb01122.x"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(99)80398-7"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0143-2885.2004.00785.x"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.don.0000145031.04236.ca"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(77)80172-6"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2004.09.008"},{"key":"e_1_2_11_109_1","first-page":"440","volume-title":"Endodontology. Biologic Considerations in Endodontic Procedures","author":"Seltzer S","year":"1988"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(64)90047-7"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(71)90040-5"},{"key":"e_1_2_11_112_1","first-page":"304","article-title":"Reduction of intracanal bacteria using nickel\u2010titanium rotary instrumentation and various medications","volume":"2","author":"Shuping GB","year":"2000","journal-title":"Journal of Endodontics"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1999.tb00776.x"},{"key":"e_1_2_11_114_1","first-page":"330","article-title":"The apex: how critical is it","volume":"42","author":"Simon JHS","year":"1994","journal-title":"General Dentistry"},{"key":"e_1_2_11_115_1","first-page":"425","volume-title":"Pathways of the Pulp","author":"Simon JHS","year":"1998"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2001.00396.x"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.1999.00275.x"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2001.00374.x"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(97)80309-3"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2004.00144.x"},{"key":"e_1_2_11_121_1","first-page":"145","volume-title":"Textbook of Endodontology","author":"Skaug N","year":"2003"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1999.0038"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(66)90043-0"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-1546.2002.20104.x"},{"key":"e_1_2_11_125_1","first-page":"692","volume-title":"Pathways of the Pulp","author":"Stabholz A","year":"1994"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1990.tb00400.x"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(85)90172-0"},{"issue":"21","key":"e_1_2_11_128_1","first-page":"1","article-title":"The dependence of the results of pulp therapy on certain factors: an analytic study based on radiographic and clinical follow\u2010up examination","volume":"14","author":"Strindberg LZ","year":"1956","journal-title":"Acta Odontologica Scandinavica"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(80)80021-5"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1546.2004.00112.x"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(99)80292-1"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.1998.00134.x"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)81202-1"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb02211.x"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(07)80198-1"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1546.2003.00039.x"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1987.tb00549.x"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-9657.2000.016005218.x"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1546.2003.00031.x"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-1546.2002.10104.x"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(74)80042-6"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(69)90079-6"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)81702-4"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2004.00915.x"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200212000-00011"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.116154"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(76)80045-3"},{"key":"e_1_2_11_148_1","volume-title":"Principles and Practice of Endodontics","author":"Walton RE","year":"1996"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1988.tb00949.x"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)80605-9"},{"key":"e_1_2_11_151_1","first-page":"203","volume-title":"Pathways of the Pulp","author":"West JD","year":"1998"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1993.tb00540.x"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2001.00361.x"},{"key":"e_1_2_11_154_1","article-title":"Timeliness and effectiveness in the surgical management of persistent post\u2010treatment periapical pathosis","author":"Wu M\u2010K","year":"2006","journal-title":"Endodontic Topics"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2000.106344"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(00)80023-2"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2003.00646.x"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(82)90196-7"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2591.2006.01092.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2591.2006.01092.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T21:54:03Z","timestamp":1697147643000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2591.2006.01092.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,13]]},"references-count":157,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1111\/j.1365-2591.2006.01092.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2591.2006.01092.x","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,13]]},"assertion":[{"value":"2006-03-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}