{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T01:11:53Z","timestamp":1772932313587,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,3,10]],"date-time":"2006-03-10T00:00:00Z","timestamp":1141948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> To investigate the hypothesis that different haemostatic agents could impair the histological response of human pulps capped with calcium hydroxide.<\/jats:p><jats:p><jats:bold>Methodology\u2002<\/jats:bold> Forty\u2010five third molars scheduled for extraction were selected. Class I cavities with pulp exposures were prepared. Three agents were used to control bleeding: 0.9% saline solution (control, <jats:italic>n<\/jats:italic>\u2003=\u200314), 5.25% sodium hypochlorite (<jats:italic>n<\/jats:italic>\u2003=\u200316) and 2% chlorhexidine digluconate (<jats:italic>n<\/jats:italic>\u2003=\u200315). The pulps were dressed with hard\u2010setting calcium hydroxide cement. After 7, 30 or 90\u2003days, teeth were extracted, formalin\u2010fixed and prepared for histochemical techniques. The biological response was categorized using the following criteria: inflammatory response, soft tissue organization, reactionary dentine and reparative dentine. Data were submitted to statistical analysis, using nonparametric Kruskal\u2013Wallis one\u2010way analysis of variance on ranks. Differences amongst groups were detected using Dunn's method.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The statistical analysis disclosed that whilst inflammatory response decreased over time, reactionary dentine deposition and reparative dentine formation increased in the latter periods of evaluation (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). The three agents had similar performances for all criteria evaluated. The conventional pulp response to calcium hydroxide was observed over time, and complete pulp healing was observed in 88% of the specimens after 90\u2003days.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The three haemostatic agents did not impair the healing process following pulp exposure and capping with calcium hydroxide at different time intervals investigated.<\/jats:p>","DOI":"10.1111\/j.1365-2591.2006.01101.x","type":"journal-article","created":{"date-parts":[[2006,3,10]],"date-time":"2006-03-10T15:13:58Z","timestamp":1142003638000},"page":"309-316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The influence of haemostatic agents on healing of healthy human dental pulp tissue capped with calcium hydroxide"],"prefix":"10.1111","volume":"39","author":[{"given":"A. F.","family":"Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. B. 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