{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:22:23Z","timestamp":1777306943396,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,5,22]],"date-time":"2006-05-22T00:00:00Z","timestamp":1148256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> To report the repair of an extensive periapical lesion of endodontic origin, following nonsurgical treatment.<\/jats:p><jats:p><jats:bold>Summary\u2002<\/jats:bold> Clinical and radiographic examination revealed an extensive periapical lesion related to tooth 22, extending from the distal surface of tooth 21 to the mesial surface of 26. The patient reported a previous history of dental trauma involving this quadrant and had been under orthodontic treatment for a year. Intraoral examination revealed an asymptomatic bony hard swelling, mainly confined to the palate. During root canal exploration irregular walls associated with 3\u2003mm of apical calcification were noted. After apical patency was obtained 1\u2003mL of bloody serous exudate was drained. Intracanal aspiration provided a further 2\u2003mL of yellow serous exudate. Following biomechanical preparation, a dressing of calcium hydroxide with anaesthetic solution was applied and replaced four times over a period of 12\u2003months. The clinical\u2013pathological picture demonstrated resolution of the lesion during this period of time. The 14\u2010month clinical and radiographic examinations revealed normal bony contour and a significant resolution of the maxillary radiolucency.<\/jats:p><jats:p><jats:bold>Key learning points\u2002<\/jats:bold> \u2022\u2002Periapical lesions of endodontic origin may develop asymptomatically and become large.<\/jats:p><jats:p>\u2022\u2002Proper biomechanical preparation followed by calcium hydroxide medication renewed periodically represents a nonsurgical approach to resolve extensive inflammatory periapical lesions.<\/jats:p>","DOI":"10.1111\/j.1365-2591.2006.01109.x","type":"journal-article","created":{"date-parts":[[2006,5,22]],"date-time":"2006-05-22T15:15:46Z","timestamp":1148310946000},"page":"566-575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Nonsurgical treatment of extensive cyst\u2010like periapical lesion of endodontic 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