{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:16:55Z","timestamp":1758701815715},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T00:00:00Z","timestamp":1164672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> To determine the mRNA expression levels of copper\u2010zinc superoxide dismutase (Cu, Zn\u2010SOD) and manganese SOD (Mn\u2010SOD) in healthy and inflamed human dental pulp tissue.<\/jats:p><jats:p><jats:bold>Methodology\u2002<\/jats:bold> Sixteen patients with symptomatic irreversible pulpitis (eight females and eight males) were selected for study. Normal healthy pulps were removed from extracted mandibular third molar teeth from 10 systemically healthy individuals (six females and four males). QRT\u2010PCR analysis of Cu, Zn\u2010SOD and Mn\u2010SOD mRNA expression was carried out in 16 cases of irreversible pulpitis and in 10 cases of systemically healthy donors. The Shapiro\u2013Wilk's test was used to test the normality of data, whereas the Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test was used to evaluate the significance of the differences between groups. Differences in the expression levels were considered to be statistically significant for <jats:italic>P<\/jats:italic>\u2010values &lt;0.05.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> A significant increase (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) occurred in both Cu, Zn\u2010SOD and Mn\u2010SOD mRNA expression in cases of irreversible pulpitis. The increase in Mn\u2010SOD level was significantly higher (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) than the change observed for Cu, Zn\u2010SOD.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> The development of pulpitis is associated with elevated transcription of both Cu, Zn\u2010SOD and Mn\u2010SOD; pulp tissue inflammation generated higher Mn\u2010SOD transcription compared with Cu, Zn\u2010SOD.<\/jats:p>","DOI":"10.1111\/j.1365-2591.2006.01196.x","type":"journal-article","created":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T13:35:53Z","timestamp":1164720953000},"page":"128-132","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Elevated expression of Cu, Zn\u2010SOD and Mn\u2010SOD mRNA in inflamed dental pulp tissue"],"prefix":"10.1111","volume":"40","author":[{"given":"C.","family":"B\u00f6d\u00f6r","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Matolcsy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bern\u00e1th","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V64.5.959.959"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1999.tb00744.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200103000-00014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05060-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2981433"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1979.59.3.527"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)81698-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0098-2997(01)00010-3"},{"key":"e_1_2_7_10_1","first-page":"412","article-title":"Biology of disease: free radicals and tissue injury","volume":"47","author":"Freeman BA","year":"1982","journal-title":"Laboratory Investigation; A Journal of Technical Methods and Pathology"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.64.070195.000525"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-5712(91)90083-B"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715769900300841"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(88)90111-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.6.10.986"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(97)80205-1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"6696","DOI":"10.1016\/S0021-9258(19)50482-3","article-title":"Regulation by cytokines of extracellular superoxide dismutase and other superoxide dismutase isoenzymes in fibroblasts","volume":"267","author":"Marklund SL","year":"1992","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)63504-5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/jlb.54.2.171","article-title":"Inflammation, immunoregulation, and inducible nitric oxide synthase","volume":"54","author":"Nussler AK","year":"1993","journal-title":"Journal of Leukocyte Biology"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411980090040701"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90010-6"},{"key":"e_1_2_7_22_1","first-page":"341","article-title":"Superoxide dismutase activity in healthy and inflamed pulp tissues of permanent teeth in children","volume":"22","author":"Tulunoglu O","year":"1998","journal-title":"The Journal of Clinical Pediatric Dentistry"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2005.00936.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1016\/S0021-9258(19)39880-1","article-title":"Regulation of manganese superoxide dismutase by lipopolysaccharide, interleukin\u20101, and tumor necrosis factor. Role in the acute inflammatory response","volume":"265","author":"Visner GA","year":"1990","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_7_25_1","first-page":"4793","article-title":"Mitochondrial superoxide dimutase. Site of synthesis and intramitochondrial localization","volume":"248","author":"Weisiger RA","year":"1973","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90153-Z"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2591.2006.01196.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2591.2006.01196.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T23:02:32Z","timestamp":1697151752000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2591.2006.01196.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,28]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1365-2591.2006.01196.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2591.2006.01196.x","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,28]]},"assertion":[{"value":"2006-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}