{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T19:03:23Z","timestamp":1776452603236,"version":"3.51.2"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,8,22]],"date-time":"2007-08-22T00:00:00Z","timestamp":1187740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> To present a systematic review of the effects of formocresol and ferric sulphate when used as medicaments in pulpotomized primary molar teeth.<\/jats:p><jats:p><jats:bold>Methodology\u2002<\/jats:bold> The study list was obtained by using MEDLINE, the Cochrane Library, EMBASE and SCI search. Only those papers which met the inclusion criteria were accepted. The quality of studies used for meta\u2010analysis was assessed by a series of validity criteria according to Jadad's scale. A systematic review and meta\u2010analysis were performed.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Eleven clinical studies comprising four randomized\u2010clinical trials (RCTs), four controlled clinical trials (CCTs) and three retrospective studies were included. The results of the meta\u2010analysis of six prospective clinical trials suggested that the two popular pulpotomy medicaments were not significantly different in terms of clinical outcomes, radiographic findings, prevalence of apical and furcal destruction, internal root resorption or pulp canal obliteration. The relative risk (RR) value and 95% CI for those parameters were 0.72 (0.43\u20131.23), 0.87 (0.59\u20131.30), 0.67 (0.27\u20131.66), 1.77 (0.56\u20135.58) and 1.41 (0.63\u20133.15), respectively. The overall clinical and radiographic success rates based on the data of treatments with ferric sulphate from the 11 studies included ranged from 78% to 100% (mean 91.6\u2003\u00b1\u20038.15%) and from 42% to 97% (mean 73.5\u2003\u00b1\u200318.40%), respectively.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> In primary molar teeth with exposure of vital pulps by caries or trauma, pulpotomies performed with either formocresol or ferric sulphate have similar clinical and radiographic success. Ferric sulphate may be recommended as a suitable replacement for formocresol.<\/jats:p>","DOI":"10.1111\/j.1365-2591.2007.01288.x","type":"journal-article","created":{"date-parts":[[2007,8,22]],"date-time":"2007-08-22T11:05:23Z","timestamp":1187780723000},"page":"751-757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Evaluation of formocresol versus ferric sulphate primary molar pulpotomy: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"40","author":[{"given":"L.","family":"Peng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(78)90096-8"},{"key":"e_1_2_7_3_1","first-page":"44","article-title":"Comparison of ferric sulfate, formocresol, and a combination of ferric sulfate\/formocresol in primary tooth vital pulpotomies: a retrospective radiographic survey","volume":"69","author":"Burnett S","year":"2002","journal-title":"Journal of Dentistry for Children"},{"key":"e_1_2_7_4_1","first-page":"44","article-title":"Long\u2010term outcomes of primary molar ferric sulfate pulpotomy and root canal therapy","volume":"26","author":"Casas MJ","year":"2004","journal-title":"Pediatric Dentistry"},{"key":"e_1_2_7_5_1","first-page":"749","article-title":"Do we still need formocresol in pediatric dentistry","volume":"71","author":"Casas MJ","year":"2005","journal-title":"Journal of the Canadian Dental Association"},{"key":"e_1_2_7_6_1","first-page":"247","article-title":"Pulpal tissue reaction to formocresol versus ferric sulfate in pulpotomized rat teeth","volume":"3","author":"Cotes O","year":"1997","journal-title":"Journal of Clinical Paediatric Dentistry"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945902024004008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-263X.2002.00355.x"},{"key":"e_1_2_7_9_1","first-page":"15","article-title":"Mineral trioxide aggregate versus formocresol in pulpotomized primary molars: a preliminary report","volume":"23","author":"Eidelman E","year":"2001","journal-title":"Pediatric Dentistry"},{"key":"e_1_2_7_10_1","first-page":"327","article-title":"A clinical study of ferric sulfate as a pulpotomy agent in primary teeth","volume":"13","author":"Fei AL","year":"1991","journal-title":"Pediatric Dentistry"},{"key":"e_1_2_7_11_1","first-page":"178","article-title":"Tissue management: a new solution to an old problem","volume":"35","author":"Fischer DE","year":"1987","journal-title":"General Dentistry"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1981.tb01081.x"},{"key":"e_1_2_7_13_1","first-page":"115","article-title":"Current concepts in vital primary pulp therapy","volume":"3","author":"Fuks AB","year":"2002","journal-title":"European Journal of Paediatric Dentistry"},{"key":"e_1_2_7_14_1","first-page":"254","article-title":"Pulp response to ferric sulfate, diluted formocresol and IRM in pulpotomized primary baboon teeth","volume":"64","author":"Fuks AB","year":"1997","journal-title":"ASDC Journal of Dentistry for Children"},{"key":"e_1_2_7_15_1","first-page":"327","article-title":"Ferric sulfate versus dilute formocresol in pulpotomized primary molars: long\u2010term follow up","volume":"19","author":"Fuks AB","year":"1997","journal-title":"Pediatric Dentistry"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345810600071401"},{"key":"e_1_2_7_17_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions: 4.2.5. 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