{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:16:31Z","timestamp":1760645791806},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,1,24]],"date-time":"2011-01-24T00:00:00Z","timestamp":1295827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:sec><jats:label \/><jats:p> <jats:bold>Silva\u2010Herzog D, Ram\u00edrez T, Mora J, Pozos AJ, Silva LAB, Silva RAB, Nelson\u2010Filho P.<\/jats:bold> Preliminary study of the inflammatory response to subcutaneous implantation of three root canal sealers. <jats:italic>International Endodontic Journal<\/jats:italic>, <jats:bold>44<\/jats:bold>, 440\u2013446, 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> To evaluate the kinetics of the inflammatory tissue response to three root canal sealers using a physicochemical method for quantification of the enhanced vascular permeability and histopathological analysis.<\/jats:p><jats:p><jats:bold>Methodology\u2002<\/jats:bold> Twenty\u2010eight male Wistar rats randomly assigned to four groups according to the evaluation periods (1, 3, 7 and 14\u2003days) were used to assess the vascular permeability and histopathological reaction to RoekoSeal, AH Plus and Sealapex (new formulation) sealers, using saline and Chloropercha as negative and positive controls, respectively. Seven rats were sacrificed per period. The biocompatibility of the sealers was evaluated spectrophotometrically and histopathologically.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> At day 14, Sealapex produced significantly more inflammatory exudate than AH Plus and RoekoSeal (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05); however, there was no significant difference between AH Plus and RoekoSeal (<jats:italic>P\u2003<\/jats:italic>&gt;<jats:italic>\u2003<\/jats:italic>0.05). Sealapex (new formulation) was the most irritating sealer, producing severe inflammation with the presence of multinucleated giant cells. RoekoSeal was the most biocompatible sealer, producing the least amount of inflammatory exudate.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> RoekoSeal root canal sealer was biocompatible when implanted in connective tissue.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2591.2011.01849.x","type":"journal-article","created":{"date-parts":[[2011,1,24]],"date-time":"2011-01-24T10:32:21Z","timestamp":1295865141000},"page":"440-446","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Preliminary study of the inflammatory response to subcutaneous implantation of three root canal sealers"],"prefix":"10.1111","volume":"44","author":[{"given":"D.","family":"Silva\u2010Herzog","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Mora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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