{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:30:34Z","timestamp":1793658634061,"version":"4.5.1"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,7,21]],"date-time":"2011-07-21T00:00:00Z","timestamp":1311206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:bold>Han L, Okiji T<\/jats:bold>. Uptake of calcium and silicon released from calcium silicate\u2013based endodontic materials into root canal dentine. <jats:italic>International Endodontic Journal<\/jats:italic>, <jats:bold>44<\/jats:bold>, 1081\u20131087, 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> To compare Biodentine and White ProRoot mineral trioxide aggregate (MTA) with regard to Ca and Si uptake by adjacent root canal dentine in the presence of phosphate\u2010buffered saline (PBS).<\/jats:p><jats:p><jats:bold>Methodology\u2002<\/jats:bold> Root canals of bovine incisor root segments were instrumented, filled with either Biodentine or MTA (<jats:italic>n<\/jats:italic>\u2003=\u200320 each) and then immersed in Ca\u2010and Mg\u2010free PBS for 1, 7, 30 or 90\u2003days (<jats:italic>n<\/jats:italic>\u2003=\u20035 each). Unfilled, unimmersed dentine specimens (<jats:italic>n<\/jats:italic>\u2003=\u20035) served as controls. The specimens were sectioned longitudinally, and the ultrastructure of the dentine\u2013material interface and the elemental composition\/distribution in the material\u2013adjacent dentine were analysed using a wavelength\u2010dispersive X\u2010ray spectroscopy electron probe microanalyser with image observation function. Data were statistically analyzed using one\u2010way <jats:sc>anova<\/jats:sc> and Tukey\u2019s honestly significant difference test or the Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Along the material\u2013dentine interface, both materials formed a tag\u2010like structure that was composed of either Ca\u2010 and P\u2010rich crystalline deposits or the material itself. The width of a Ca\u2010 and Si\u2010rich layer detected along the dentine layer of the material\u2013dentine interface showed increases over time. The Ca\u2010 and Si\u2010rich layer width was significantly larger (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) in Biodentine than MTA at 30 and 90\u2003days.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Both Biodentine and MTA caused the uptake of Ca and Si in the adjacent root canal dentine in the presence of PBS. 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