{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:20:40Z","timestamp":1762374040046},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,9,8]],"date-time":"2011-09-08T00:00:00Z","timestamp":1315440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec><jats:label \/><jats:p><jats:bold>Danesh F, Vahid A, Jahanbani J, Mashhadiabbas F, Arman E.<\/jats:bold> Effect of white mineral trioxide aggregate compared with biomimetic carbonated apatite on dentine bridge formation and inflammatory response in a dental pulp model. <jats:italic>International Endodontic Journal<\/jats:italic>, <jats:bold>45<\/jats:bold>, 26\u201334, 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> To evaluate the effects of apatite precipitation on the biocompatibility and hard tissue induction properties of white mineral trioxide aggregate (WMTA) in a dental pulp model.<\/jats:p><jats:p><jats:bold>Methodology\u2002<\/jats:bold> Pulp exposures were created on the axial walls of 32 sound canine teeth of eight dogs. Four additional sound teeth served as controls. The pulps were capped either with WMTA or apatite derivatives [biomimetic carbonated apatite (BCAp)] in the interaction of WMTA with a synthetic tissue fluid and restored with zinc oxide\u2013eugenol cement. After 7 and 70\u2003days, the animals were killed, and the histological specimens taken from the teeth were stained with haematoxylin and eosin for histomorphological evaluation. The Brown and Brenn technique was employed to stain bacteria. The data were subjected to nonparametric Kruskall\u2013Wallis analysis and Mann\u2013Whitney <jats:italic>U<\/jats:italic>_tests.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Biomimetic carbonated apatite did not induce hard tissue bridge formation. WMTA performed significantly better than BCAp in this respect at both periods (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.05). BCAp was associated with a significantly greater inflammatory response as compared with WMTA after 7\u2003days (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.05). Both materials were associated with similar reactions after 70\u2003days (<jats:italic>P\u2003<\/jats:italic>&gt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> White mineral trioxide aggregate induced hard tissue formation via a mechanism other than that postulated via apatite formation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2591.2011.01943.x","type":"journal-article","created":{"date-parts":[[2011,9,8]],"date-time":"2011-09-08T16:12:30Z","timestamp":1315498350000},"page":"26-34","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of white mineral trioxide aggregate compared with biomimetic carbonated apatite on dentine bridge formation and inflammatory response in a dental pulp 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