{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:16:47Z","timestamp":1791289007146,"version":"4.3.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,2,10]],"date-time":"2012-02-10T00:00:00Z","timestamp":1328832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:bold>Lee Y, Go EJ, Jung HS, Kim E, Jung IY, Lee SJ.<\/jats:bold> Immunohistochemical analysis of pulpal regeneration by nestin expression in replanted teeth. <jats:italic>International Endodontic Journal<\/jats:italic>, <jats:bold>45<\/jats:bold>, 652\u2013659, 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> To investigate dental pulp healing after tooth replantation in rats using nestin as an odontoblastic marker for immunohistochemical analysis.<\/jats:p><jats:p><jats:bold>Methodology\u2002<\/jats:bold> Twenty\u2010five maxillary right first molars from 25 female Sprague\u2010Dawley rats, aged 4\u2003weeks post\u2010natally, were extracted and immediately repositioned in the original socket within 5\u2003s. Five rats each were later killed on days 3, 5 and weeks 1, 2 and 4. The maxillae were removed <jats:italic>en bloc<\/jats:italic> and the tissue samples containing the maxillary right first molars were decalcified, sectioned, mounted and stained with anti\u2010nestin antibody to be observed under a light microscope.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> At 3\u2003days after replantation, there was a localized inflammatory reaction, but pulp revascularization and healing had begun in the root area. At 5\u2003days after replantation, odontoblast\u2010like cells were observed. Reparative dentine deposition was observed beneath the pulp\u2010dentine border from 1\u2003week after replantation, and gradually increased until 2\u2003weeks after replantation. The presence of odontoblast\u2010like cells and the formation of reparative dentine continued from the first week throughout the experimental period. At week four, deposition of osteodentine and cementum\u2010like tissues were observed.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Pulpal mineralization after replantation initially occurred via the deposition of reparative dentine, followed by the deposition of osteodentine and cementum\u2010like tissues in rat teeth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2591.2012.02024.x","type":"journal-article","created":{"date-parts":[[2012,2,10]],"date-time":"2012-02-10T18:33:19Z","timestamp":1328898799000},"page":"652-659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Immunohistochemical analysis of pulpal regeneration by nestin expression in replanted teeth"],"prefix":"10.1111","volume":"45","author":[{"given":"Y.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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