{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T02:28:54Z","timestamp":1781231334926,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T00:00:00Z","timestamp":1337731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:bold>Iglesias\u2010Linares A, Ya\u00f1ez\u2010Vico RM, Ballesta S, Ortiz\u2010Ariza E, Mendoza\u2010Mendoza A, Perea E, Solano\u2010Reina E.<\/jats:bold>Interleukin 1 gene cluster SNPs (rs1800587, rs1143634) influences post\u2010orthodontic root resorption in endodontic and their contralateral vital control teeth differently.<jats:italic>International Endodontic Journal<\/jats:italic>,\u00a0<jats:bold>45<\/jats:bold>, 1018\u20131026, 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold>To investigate whether the genetic variants of the interleukin\u20101 gene cluster (<jats:italic>IL1<\/jats:italic>) are associated with a possible genetically induced variability in post\u2010orthodontic external apical root resorption (EARR) in root filled teeth and their control counterparts with vital pulps.<\/jats:p><jats:p><jats:bold>Methodology\u2002<\/jats:bold>One hundred and forty\u2010six maxillary premolars were evaluated radiographically following orthodontic treatment. Genetic screening was performed on orthodontic patients for two single\u2010nucleotide polymorphisms (SNPs: rs1800587 and rs1143634) in the<jats:italic>IL1<\/jats:italic>gene cluster. Subjects were divided into two groups according to the presence or absence of radiographic post\u2010orthodontic EARR (&gt;2\u2003mm) in root filled teeth and their controls with vital pulps. Logistic regression analysis was performed to obtain an adjusted estimation between EARR and<jats:italic>IL1<\/jats:italic>polymorphisms. Allelic frequencies, genotype distributions, and adjusted odds ratio (OR), at 95% confidence interval, were also calculated.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Whilst no clear statistical association was found for gene variations in<jats:italic>IL1A<\/jats:italic>, a sound association was found in the comparative analysis of subjects homozygous [2\/2(TT)] for the<jats:italic>IL1B<\/jats:italic>gene, which resulted in a two times increased risk of suffering post\u2010orthodontic EARR in root filled teeth [OR, 2.032 (<jats:italic>P<\/jats:italic>\u2003=\u20030.031); CI,1.99\u201314.77] when compared with their controls with vital pulps. There was, however, a shared predisposition to EARR in controls with vital pulps and root filled teeth of subjects homozygous for allele 1 [OR, 5.05 (<jats:italic>P<\/jats:italic>\u2003=\u20030.002)] and [OR, 2.77 (<jats:italic>P<\/jats:italic>\u2003=\u20030.037)], respectively.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>Genetic variations in the interleukin\u20101\u03b2 gene (rs1143634) predispose root filled teeth to EARR for matched pairs secondary to orthodontic treatment in a different way from their control teeth with vital pulps in subjects homozygous for allele 2 [2\/2(TT)].<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2591.2012.02065.x","type":"journal-article","created":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T17:27:37Z","timestamp":1333992457000},"page":"1018-1026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Interleukin 1 gene cluster SNPs (rs1800587, rs1143634) influences post\u2010orthodontic root resorption in endodontic and their contralateral vital control teeth differently"],"prefix":"10.1111","volume":"45","author":[{"given":"A.","family":"Iglesias\u2010Linares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. M.","family":"Ya\u00f1ez\u2010Vico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ballesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ortiz\u2010Ariza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mendoza\u2010Mendoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Perea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Solano\u2010Reina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mod.2003.42"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200506"},{"key":"e_1_2_7_4_1","first-page":"383","article-title":"Root resorption associated with orthodontic force in IL\u20101Beta knockout mouse","volume":"4","author":"Al\u2010Qawasmi RA","year":"2004","journal-title":"Journal of Musculoskeletal & Neuronal Interactions"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2478\/aoj-2006-0017","article-title":"Root resorption after orthodontic treatment","volume":"22","author":"Armstrong D","year":"2006","journal-title":"Australian Orthodontic Journal"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2007.10.051"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(97)80353-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(05)81763-9"},{"key":"e_1_2_7_9_1","first-page":"180","article-title":"Orthodontically induced inflammatory root resorption. Part II: the clinical aspects","volume":"72","author":"Brezniak N","year":"2002","journal-title":"Angle Orthodontist"},{"key":"e_1_2_7_10_1","first-page":"786","article-title":"A comparison of three methods to accurately measure root length","volume":"74","author":"Brezniak N","year":"2004","journal-title":"Angle Orthodontist"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(03)00166-5"},{"key":"e_1_2_7_12_1","volume-title":"Reabsor\u00e7\u00f5es dent\u00e1rias nas especialidades cl\u00ednicas","author":"Consolaro A","year":"2005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(86)90111-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2010.01802.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01184.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.140102.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-9657.2003.00154.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01026.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00056-009-8808-6"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(97)70189-6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-6343.2009.01458.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130401500205"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(83)90322-6"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2006.04.022"},{"key":"e_1_2_7_25_1","first-page":"50","article-title":"IL\u201010 genotype predicts serum levels of adhesion molecules, inflammation and atherosclerosis in hemodialysis patients","volume":"19","author":"Kahraman S","year":"2006","journal-title":"Journal of Nephrology"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509338914"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2370.2004.00476.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(05)81678-6"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(96)80263-9"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.01.009"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.05.029"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1986.tb00119.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2007.01.032"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.06.016"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1992.tb01480.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-008-0488-6"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-6343.2004.00286.x"},{"key":"e_1_2_7_38_1","volume-title":"Nonparametric statistics for the behavioural sciences","author":"Siegel S","year":"1988"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-77572009000500031"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(90)70086-R"},{"key":"e_1_2_7_41_1","first-page":"28","article-title":"R\u00e9sum\u00e9 of the literature on root resorption","volume":"12","author":"Steadman R","year":"1942","journal-title":"Angle Orthodontist"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/24.1.43"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2009.06.021"},{"key":"e_1_2_7_44_1","first-page":"235","article-title":"The effects of tooth movement upon endodontically treated teeth","volume":"44","author":"Wickwire NA","year":"1974","journal-title":"Angle Orthodontist"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23396"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2591.2012.02065.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2591.2012.02065.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T01:16:00Z","timestamp":1713834960000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2591.2012.02065.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,23]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1365-2591.2012.02065.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2591.2012.02065.x","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,23]]},"assertion":[{"value":"2012-05-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}