{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:45:04Z","timestamp":1760888704599},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,7,18]],"date-time":"2012-07-18T00:00:00Z","timestamp":1342569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the prevalence of hyaline ring granulomas (<jats:styled-content style=\"fixed-case\">HRG<\/jats:styled-content>s) in a large case series of inflammatory odontogenic cysts, and to investigate the nature of these structures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>All records from the patients diagnosed with inflammatory odontogenic cysts between January 1970 and April 2009 were reviewed. Histologic sections were evaluated by light microscopy and cases with <jats:styled-content style=\"fixed-case\">HRG<\/jats:styled-content>s for which sufficient biological material was available were submitted to histochemical analysis (<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>asson's trichrome) and immunohistochemistry (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>68 and collagen <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two (3.3%) of the 661 cases of inflammatory odontogenic cysts diagnosed during the study period presented <jats:styled-content style=\"fixed-case\">HRG<\/jats:styled-content>s. The relative frequency of <jats:styled-content style=\"fixed-case\">HRG<\/jats:styled-content>s was higher amongst residual radicular cysts (6.1%), followed by paradental cysts (5.6%) and radicular cysts (3.0%). <jats:styled-content style=\"fixed-case\">HRG<\/jats:styled-content>s appeared as roughly circular homogeneous\/fibrillar masses in 14 (63.6%) cases and as round structures enclosing amorphous material in 3 (13.6%) cases. Most (77.8%) roughly circular homogeneous\/fibrillar masses were positive for collagen, whereas all (100.0%) round structures enclosing amorphous material were negative for this protein. Immunohistochemistry showed that most mononucleated cells and all multinucleated giant cells were positive for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>68, but negative for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34, in all cases. In addition, collagen <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> immunostaining was negative in amorphous structures and weakly positive in homogeneous\/fibrillar masses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present results suggest a very low frequency of <jats:styled-content style=\"fixed-case\">HRG<\/jats:styled-content>s in inflammatory odontogenic cysts and support the hypothesis that these structures arise from the implantation of foreign material, most likely food particles of plant or vegetable origin. The diverse microscopic features of <jats:styled-content style=\"fixed-case\">HRG<\/jats:styled-content> possibly represent different developmental stages of this structure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2591.2012.02086.x","type":"journal-article","created":{"date-parts":[[2012,5,28]],"date-time":"2012-05-28T02:45:39Z","timestamp":1338173139000},"page":"20-29","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of the frequency and nature of hyaline ring granulomas in inflammatory odontogenic cysts"],"prefix":"10.1111","volume":"46","author":[{"given":"\u00c1. C. G.","family":"Henriques","sequence":"first","affiliation":[{"name":"Department of Dentistry Federal University of Rio Grande do Norte Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Rio Grande do Norte Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. F. W.","family":"Nonaka","sequence":"additional","affiliation":[{"name":"Department of Dentistry State University of Para\u00edba Campina Grande PB Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Rio Grande do Norte Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. P.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Rio Grande do Norte Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C. 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