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However, it is becoming increasingly evident that both point mutations and large\u2010scale deletions may have an impact on sperm motility and morphology. We discuss the implications of these rearrangements in the context of the clinical setting. We further discuss the possible consequences resulting from the transmission of sperm mtDNA deletions to the offspring. The role of nucleo\u2010cytoplasmic interaction is investigated in the context of nuclear transcription and replication factors that regulate mtDNA transcription and replication.<\/jats:p>","DOI":"10.1111\/j.1365-2605.2005.00515.x","type":"journal-article","created":{"date-parts":[[2005,3,21]],"date-time":"2005-03-21T22:09:27Z","timestamp":1111442967000},"page":"65-73","source":"Crossref","is-referenced-by-count":105,"title":["The impact of mitochondrial genetics on male infertility"],"prefix":"10.1111","volume":"28","author":[{"given":"JUSTIN C. 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