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In human males, abnormal reproductive development can manifest as a suite of symptoms, described collectively as testicular dysgenesis syndrome (TDS). TDS is also described as demasculinization or feminization of the male phenotype. The suite includes cryptorchidism, in situ germ cell carcinoma of the testis and overt testicular cancer, reduced semen quality, and hypospadias. In this paper, we review examples of TDS among comparative species. Wildlife exposed to environmental contaminants are susceptible to some of the same developmental abnormalities and subsequent symptoms as those seen in human males with TDS. There are additional end points, which are also discussed. In some cases, the symptoms are more severe than those normally seen in humans with TDS (i.e. oocytes developing within the testis) because some non\u2010mammalian species exhibit greater innate reproductive plasticity, and are thus more easily feminized. Based on our review, we present an approach regarding the ontogeny of TDS. Namely, we suggest that male susceptibility to the androgynizing influences of environmental contaminants originates in the sexually undifferentiated embryo, which, in almost all species, including humans, consists of bipotential reproductive tissues. These tissues can develop as either male or female and their ultimate direction depends on the environment in which they develop.<\/jats:p>","DOI":"10.1111\/j.1365-2605.2005.00631.x","type":"journal-article","created":{"date-parts":[[2006,2,7]],"date-time":"2006-02-07T10:20:01Z","timestamp":1139307601000},"page":"109-121","source":"Crossref","is-referenced-by-count":100,"title":["Reproductive dysgenesis in wildlife: a comparative view"],"prefix":"10.1111","volume":"29","author":[{"given":"Thea M.","family":"Edwards","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon C.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Louis J.","family":"Guillette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,7]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000122920"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/432048a"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0438"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2003.10.008"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000114157"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2004.04703.x"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1000013"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.20068"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.2307\/1382247"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002449900475"},{"key":"e_1_2_2_12_1","first-page":"90","volume-title":"Environmental Hormones: The Scientific Basis of Endocrine Disruption","author":"Boisen K. 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