{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T05:56:41Z","timestamp":1771999001945,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T00:00:00Z","timestamp":1148601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Andrology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Irradiation has been widely reported to damage organisms by attacking on proteins, nucleic acid and lipids in cells. However, radiation hormesis after low\u2010dose irradiation has become the focus of research in radiobiology in recent years. To investigate the effects of pre\u2010exposure of mouse brain with low\u2010dose <jats:sup>12<\/jats:sup>C<jats:sup>6+<\/jats:sup> ion or <jats:sup>60<\/jats:sup>Co gamma (<jats:italic>\u03b3<\/jats:italic>)\u2010ray on male reproductive endocrine capacity induced by subsequent high\u2010dose irradiation, the brains of the B6C3F<jats:sub>1<\/jats:sub> hybrid strain male mice were irradiated with 0.05\u2003Gy of <jats:sup>12<\/jats:sup>C<jats:sup>6+<\/jats:sup> ion or <jats:sup>60<\/jats:sup>Co <jats:italic>\u03b3<\/jats:italic>\u2010ray as the pre\u2010exposure dose, and were then irradiated with 2\u2003Gy as challenging irradiation dose at 4\u2003h after pre\u2010exposure. Serum pituitary gonadotropin hormones, follicle\u2010stimulating hormone (FSH) and luteinizing hormone (LH), testosterone, testis weight, sperm count and shape were measured on the 35th day after irradiation. The results showed that there was a significant reduction in the levels of serum FSH, LH, testosterone, testis weight and sperm count, and a significant increase in sperm abnormalities by irradiation of the mouse brain with 2\u2003Gy of <jats:sup>12<\/jats:sup>C<jats:sup>6+<\/jats:sup> ion or <jats:sup>60<\/jats:sup>Co <jats:italic>\u03b3<\/jats:italic>\u2010ray. Moreover, the effects were more obvious in the group irradiated by <jats:sup>12<\/jats:sup>C<jats:sup>6+<\/jats:sup> ion than in that irradiated by <jats:sup>60<\/jats:sup>Co <jats:italic>\u03b3<\/jats:italic>\u2010ray. Pre\u2010exposure with low\u2010dose <jats:sup>12<\/jats:sup>C<jats:sup>6+<\/jats:sup> ion or <jats:sup>60<\/jats:sup>Co <jats:italic>\u03b3<\/jats:italic>\u2010ray significantly alleviated the harmful effects induced by a subsequent high\u2010dose irradiation.<\/jats:p>","DOI":"10.1111\/j.1365-2605.2006.00698.x","type":"journal-article","created":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T14:33:36Z","timestamp":1148654016000},"page":"592-596","source":"Crossref","is-referenced-by-count":16,"title":["Alleviation of pre\u2010exposure of mouse brain with low\u2010dose <sup>12<\/sup>C<sup>6+<\/sup> ion or <sup>60<\/sup>Co gamma\u2010ray on male reproductive endocrine damages induced by subsequent high\u2010dose irradiation"],"prefix":"10.1111","volume":"29","author":[{"given":"Hong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengling","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoda","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01963282"},{"key":"e_1_2_6_3_1","first-page":"146","article-title":"On the \u03b1\u2010particles of radium and their loss of range in passing through various atoms and molecules","volume":"10","author":"Bragg W.","year":"1905","journal-title":"Philosophical Magazine"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1667\/0033-7587(2001)155[0353:REOHIP]2.0.CO;2"},{"key":"e_1_2_6_5_1","first-page":"277","article-title":"Study on the mechanism of cytogenetic adaptive response induced by low dose radiation","volume":"105","author":"Cai L.","year":"1992","journal-title":"Chinese Medical Journal (English)"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00039-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199301143280203"},{"key":"e_1_2_6_8_1","first-page":"1","volume-title":"The Physics of Highly and Multiply Charged Ions, Chapter 10","author":"Kraft G.","year":"2002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(01)00126-X"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-198705000-00008"},{"key":"e_1_2_6_11_1","first-page":"13013","article-title":"Changes in lymphocyte reactivity to modulatory factors following low\u2010dose ionizing radiation","volume":"7","author":"Liu S. 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