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Testis translocation into abdominal cavity, which results in temperature elevation, does not induce expression of the Hsp70i proteins. Despite constitutive expression of testis\u2010specific Hsp70 proteins, spermatocytes are very sensitive to damage at elevated temperatures. To test whether Hsp70i protein could protect testes from heat\u2010induced damage, we have engineered transgenic mice that over\u2010express this protein selectively in spermatocytes and spermatids. We demonstrate that the testes of cryptorchid transgenic mice, like those of wild\u2010type mice, exhibit reduced weight and smaller sizes of their seminiferous tubules, disorganization of their germinal epithelium structures, appearance of multinucleated giant cells, and reduced populations of germ cells. The data show that constitutive expression of Hsp70i does not protect the seminiferous epithelium against cryptorchidism\u2010induced damage.<\/jats:p>","DOI":"10.1111\/j.1365-2605.2006.00713.x","type":"journal-article","created":{"date-parts":[[2006,10,3]],"date-time":"2006-10-03T07:33:00Z","timestamp":1159860780000},"page":"80-87","source":"Crossref","is-referenced-by-count":17,"title":["Inducible 70\u2003kDa heat shock protein does not protect spermatogenic cells from damage induced by cryptorchidism"],"prefix":"10.1111","volume":"30","author":[{"given":"Wieslawa","family":"Widlak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boleslaw","family":"Winiarski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Krawczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Vydra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Malusecka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zdzislaw","family":"Krawczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.8.8.3260"},{"key":"e_1_2_5_3_1","first-page":"47","article-title":"Effect of prolonged cryptorchidism on germ cell apoptosis and testicular sperm count","volume":"6","author":"Barqawi A.","year":"2003","journal-title":"Asian Journal of Andrology"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)01553-1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01284"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/35019501"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-005-0813-7"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.09.110193.003125"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(01)00556-X"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.24.8575-8591.2001"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(90)90302-8"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1033"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod61.2.393"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(98)80143-9"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.59.353"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.020065"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1999.4455"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)59640-X"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(98)00028-X"},{"key":"e_1_2_5_20_1","first-page":"183","article-title":"Assessment of germ cell apoptosis in cryptorchid rats","volume":"4","author":"Kocak I.","year":"2002","journal-title":"Asian Journal of Andrology"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00580647"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.107.4.1317"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01267.2001"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950180708"},{"key":"e_1_2_5_25_1","first-page":"43","volume-title":"Handbook of Experimental Pharmacology","author":"Li G. 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