{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:09:49Z","timestamp":1771484989217,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T00:00:00Z","timestamp":1164585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Andrology"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> The objective of this study was to evaluate whether serum <jats:italic>Chlamydia trachomatis<\/jats:italic> immunoglobulin\u2010A (IgA), IgM and <jats:italic>C.\u00a0trachomatis<\/jats:italic> heat shock protein 60 (CHSP60) IgG are of additional value to <jats:italic>C.\u00a0trachomatis<\/jats:italic> IgG regarding the impact on fecundity in infertile couples, and to relate <jats:italic>C.\u00a0trachomatis<\/jats:italic> serum antibodies to semen characteristics, diagnoses and pregnancy outcome.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A total of 226 infertile couples, previously tested for <jats:italic>C.\u00a0trachomatis<\/jats:italic> IgG, were tested for <jats:italic>C.\u00a0trachomatis<\/jats:italic> IgA, IgM and CHSP60 IgG, and semen samples from all men were analysed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>  <jats:italic>Chlamydia trachomatis<\/jats:italic> serum IgA in men (but not in women) correlated with reduced chances of achieving pregnancy [<jats:italic>p<\/jats:italic>\u2003=\u20030.021, relative risk (RR)\u2003=0.65, 95% confidence interval (CI) 0.42\u20131.005] and in combination with <jats:italic>C.\u00a0trachomatis<\/jats:italic> IgG the chance was further reduced (<jats:italic>p<\/jats:italic>\u2003=0.001, RR\u2003=\u20030.35, 95% CI 0.15\u20130.84). <jats:italic>Chlamydia trachomatis<\/jats:italic> serum IgA was also significantly correlated with reduced motility of the spermatozoa (\u22128.7%, <jats:italic>p<\/jats:italic>\u2003=\u20030.023), increased number of dead spermatozoa (+10.5%, <jats:italic>p<\/jats:italic>\u2003=\u20030.014) and higher prevalence of leucocytes in semen (+122%, <jats:italic>p<\/jats:italic>\u2003=\u20030.005), and in combination with <jats:italic>C.\u00a0trachomatis<\/jats:italic> IgG positivity, there was also a decrease in sperm concentration (\u221235%, <jats:italic>p<\/jats:italic>\u2003=\u20030.033), the number of progressive spermatozoa (\u221214.8%, <jats:italic>p<\/jats:italic>\u2003=\u20030.029) and a rise in the teratozoospermia index (+4.4%, <jats:italic>p<\/jats:italic>\u2003=\u20030.010). CHSP60 IgG correlated with reduced motility (\u22125.6%, <jats:italic>p<\/jats:italic>\u2003=\u20030.033), and in the women to tubal factor infertility (<jats:italic>p<\/jats:italic>\u2003=\u20030.033), but no correlations of <jats:italic>C.\u00a0trachomatis<\/jats:italic> serum IgM or CHSP60 IgG with pregnancy rates were found.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>  <jats:italic>Chlamydia trachomatis<\/jats:italic> serum IgA in the male partner of the infertile couple has an additive value to IgG in predicting pregnancy chances, and serum IgA and IgG are associated with subtle negative changes in semen characteristics.<\/jats:p>","DOI":"10.1111\/j.1365-2605.2006.00718.x","type":"journal-article","created":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T20:17:52Z","timestamp":1164658672000},"page":"99-107","source":"Crossref","is-referenced-by-count":28,"title":["Male serum <i>Chlamydia trachomatis<\/i> IgA and IgG, but not heat shock protein 60\u2003IgG, correlates with negatively affected semen characteristics and lower pregnancy rates in the infertile couple"],"prefix":"10.1111","volume":"30","author":[{"given":"A.","family":"Idahl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Abramsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Kumlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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