{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T05:50:09Z","timestamp":1697176209718},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T00:00:00Z","timestamp":1164585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Andrology"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Cerebrovascular disease may impair the autonomic control of peripheral organs including the male urogenital tract. This study investigates the effect of cortico\u2010parietal focal ischaemia on the adrenergic and purinergic transmission in isolated epididymal and prostatic portion of rat vas deferens.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Focal brain ischaemia was induced in male rats by photochemical activation following rose bengal intravenous injection. Twenty\u2010four hours following brain ischaemia, cumulative and non\u2010cumulative concentration\u2013response curves were obtained for noradrenaline and <jats:italic>\u03b1<\/jats:italic>,<jats:italic>\u03b2<\/jats:italic>\u2010methylene ATP in the right and left epididymal and prostatic portions of the vas deferens. Both portions were also stimulated by single\u2010pulse or pulse trains at 2\u201330\u2003Hz to produce isometric contractions.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In both portions from ischaemic rats the response to exogenous noradrenaline was markedly depressed compared with controls. Acute cortico\u2010parietal ischaemia almost completely abolished the adrenergic phase of the response to single\u2010pulse stimulation in the epididymal portion of the vas deferens. In addition, brain ischaemia deeply depressed phasic and tonic contractions of the frequency\u2013response curve in both portions of bisected vas deferens.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Cortico\u2010parietal ischaemia produces a selective noradrenergic impairment at the level of male sexual secondary organs that may contribute to sexual dysfunction after stroke.<\/jats:p>","DOI":"10.1111\/j.1365-2605.2006.00719.x","type":"journal-article","created":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T20:17:52Z","timestamp":1164658672000},"page":"129-136","source":"Crossref","is-referenced-by-count":3,"title":["Selective impairment of noradrenergic transmission in the bisected rat vas deferens following photochemically\u2010induced cerebral ischaemia"],"prefix":"10.1111","volume":"30","author":[{"given":"C.","family":"Boselli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Gioglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Preda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Govoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(87)90207-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2680.2000.00176.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704628"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1983.tb11010.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)01822-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990510)407:3<438::AID-CNE11>3.0.CO;2-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901393"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1992.tb14241.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1986.00520100048013"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2000.00560.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1566-0702(01)00292-2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2605.2003.00392.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(96)00828-X"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530310039010"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.16.6.749"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(99)00084-4"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00077-5"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.4.787"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1998.tb07321.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.4.715"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02318379"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/47495"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(00)00266-1"},{"key":"e_1_2_6_25_1","volume-title":"Manual of Pharmacologic Calculations with Computer Programs","author":"Tallarida R. J.","year":"1987"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)02452-4"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00237-7"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410170513"}],"container-title":["International Journal of Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2605.2006.00719.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2605.2006.00719.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T14:49:50Z","timestamp":1697122190000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2605.2006.00719.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,27]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1111\/j.1365-2605.2006.00719.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2605.2006.00719.x","archive":["Portico"],"relation":{},"ISSN":["0105-6263","1365-2605"],"issn-type":[{"value":"0105-6263","type":"print"},{"value":"1365-2605","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,27]]}}}