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The aim of this study was to compare the expression of P\u2010cadherin in unilaterally cryptorchid and busulphan\u2010treated rat testes using immunohistochemistry. The pattern of expression of P\u2010cadherin in the seminiferous epithelium changed with the stage of the seminiferous epithelium. The membranes of round spermatids and membranes and cytoplasm of spermatocytes were strongly positive. Our experiments revealed that busulphan treatment (2 doses \u2013 10\u2003mg\/kg of body weight \u2013 21\u2003days apart) and cryptorchism led to destructive changes in the structure of seminiferous tubules, together with the decrease in P\u2010cadherin expression. The expression of P\u2010cadherin disappeared in the spermatids segregated from the epithelium while segregated spermatocytes remained still positive for P\u2010cadherin during the 3\u2010 to 11\u2010day cryptorchid period. In busulphan\u2010treated animals, the expression of P\u2010cadherin was dependent on the presence or absence of the spermatocytes and spermatids in the tubules. Strong positivity for P\u2010cadherin was observed in the spermatocytes that re\u2010appeared in the regenerating seminiferous epithelium. We suggest that P\u2010cadherin participates in the architecture of adherens junctions in testis, plays an important role in maintaining normal spermatogenesis and that cryptorchism and busulphan treatment lead to adherens junction disintegration.<\/jats:p>","DOI":"10.1111\/j.1365-2605.2006.00738.x","type":"journal-article","created":{"date-parts":[[2007,2,12]],"date-time":"2007-02-12T09:20:56Z","timestamp":1171272056000},"page":"430-438","source":"Crossref","is-referenced-by-count":7,"title":["Changes in the expression of P\u2010cadherin in the normal, cryptorchid and busulphan\u2010treated rat 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