{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:00:38Z","timestamp":1791925238258,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,10,30]],"date-time":"2007-10-30T00:00:00Z","timestamp":1193702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Andrology"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The link between endocrine disruptors and altered blood glucose homeostasis has been recently suggested. Epidemiological studies have correlated levels of phthalates, dioxins and persistent organic pollutants with alterations of blood glucose homeostasis in humans. Environmentally relevant doses of the ubiquitous endocrine disruptor bisphenol\u2010A (BPA) have profound effects on mice endocrine pancreas \u2013 an essential tissue involved in glucose metabolism. BPA exerts rapid non\u2010genomic effects on insulin releasing \u03b2\u2010cells and glucagon releasing \u03b1\u2010cells within freshly isolated islets of Langerhans. In vivo, a single BPA injection of 10\u03bcg\/kg rapidly increases plasma insulin and concomitantly decreases glycaemia. When mice were treated with BPA 100\u03bcg\/kg\/day for 4\u2003days, the environmental oestrogen produced an increase in \u03b2\u2010cell insulin content along with a post\u2010prandial hyperinsulinaemia and insulin resistance. The results reviewed here demonstrate that doses well below the current lowest observed adverse effect level considered by the US\u2010EPA, disrupt pancreatic \u03b2\u2010cell function producing insulin resistance in male mice. Therefore, this altered blood glucose homeostasis by BPA exposure may enhance the risk of developing type II diabetes.<\/jats:p>","DOI":"10.1111\/j.1365-2605.2007.00832.x","type":"journal-article","created":{"date-parts":[[2007,10,30]],"date-time":"2007-10-30T23:24:23Z","timestamp":1193786663000},"page":"194-200","source":"Crossref","is-referenced-by-count":165,"title":["Bisphenol\u2010A disruption of the endocrine pancreas and blood glucose homeostasis"],"prefix":"10.1111","volume":"31","author":[{"given":"A. B.","family":"Ropero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Alonso\u2010Magdalena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Garc\u00eda\u2010Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ripoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nadal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2005.01.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8451"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2006.07.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.68.040104.124723"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.06.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.4.8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2006.11.002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/1354750032000158420"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1097103"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602956103"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0543"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1042\/cs1020151","article-title":"Sex steroids and insulin resistance","volume":"102","author":"Livingstone C.","year":"2002","journal-title":"Clinical Science (London)"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0022-2275(20)30108-5","article-title":"Bisphenol A in combination with insulin can accelerate the conversion of 3T3\u2010L1 fibroblasts to adipocytes","volume":"43","author":"Masuno H.","year":"2002","journal-title":"Journal of Lipid Research"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.13.1341"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.0085z.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.21.11603"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"27036","DOI":"10.1016\/S0021-9258(18)47122-0","article-title":"Distinct properties of the cAMP\u2010responsive element of the rat insulin I gene","volume":"269","author":"Oetjen E.","year":"1994","journal-title":"The Journal of Biological Chemistry"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.2007.S405"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0313fje"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.00397.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.16.3.0794"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2006.09.019"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-4-28"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7713"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(99)00471-5"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9882"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(01)00142-8"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2002.6407"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2007.05.010"}],"container-title":["International Journal of Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2605.2007.00832.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2605.2007.00832.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T22:32:57Z","timestamp":1697149977000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2605.2007.00832.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,30]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1111\/j.1365-2605.2007.00832.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2605.2007.00832.x","archive":["Portico"],"relation":{},"ISSN":["0105-6263","1365-2605"],"issn-type":[{"value":"0105-6263","type":"print"},{"value":"1365-2605","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,30]]}}}