{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T15:36:51Z","timestamp":1769873811346,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T00:00:00Z","timestamp":1317081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Andrology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A total of 151 patients (age: 24\u201374\u2003years, mean: 55\u2003\u00b1\u200310.3) diagnosed with Peyronie\u2019s disease were enrolled in a non\u2010surgical treatment. In addition to medical histories and physical examinations, all patients underwent the following tests: penile ultrasound, IIEF questionnaire and photographic documentation. The penile curvature was measured by taking a photograph during maximum erection. All 151 patients were treated at different times and with different combinations of drugs, and afterwards, they were clinically studied and divided into five different treatment groups: 1st\u2003=\u2003verapamil (injection\u2003+\u2003iontophoresis)\u2003+\u2003vitamin E\u2003+\u2003topical diclofenac\u2003+\u2003blueberries; 2nd\u2003=\u2003verapamil (injection\u2003+\u2003iontophoresis)\u2003+\u2003vitamin E\u2003+\u2003topical diclofenac\u2003+\u2003propolis; 3rd\u2003=\u2003verapamil (injection)\u2003+\u2003vitamin E\u2003+\u2003topical Diclofenac; 4th\u2003=\u2003verapamil (iontophoresis)\u2003+\u2003vitamin E\u2003+\u2003topical diclofenac; 5th\u2003=\u2003verapamil (injection\u2003+\u2003iontophoresis)\u2003+\u2003topical diclofenac\u2003+\u2003blueberries\u2003+\u2003propolis. All patients were treated for 6\u2003months after which they underwent the same follow\u2010up tests as performed prior to the treatment. The following was achieved: group 1 had the most reduction in plaque size (\u221266.4%; <jats:italic>p<\/jats:italic>\u2003=\u20030.000), group 2 obtained the highest rate where penile curvature disappeared (24.5%; <jats:italic>p<\/jats:italic>\u2003=\u20030.019); the best results with reference to decrease in curvature angle were reached by the 2nd group (<jats:bold>\u2212<\/jats:bold>14\u00b0) and group 1 obtained <jats:bold>\u2212<\/jats:bold>9.6\u00b0 (<jats:italic>p<\/jats:italic>\u2003=\u20030.000).<\/jats:p>","DOI":"10.1111\/j.1365-2605.2011.01219.x","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T05:43:53Z","timestamp":1317188633000},"page":"521-527","source":"Crossref","is-referenced-by-count":16,"title":["Effectiveness of antioxidants (propolis, blueberry, vitamin E) associated with verapamil in the medical management of Peyronie\u2019s disease: a study of 151 cases"],"prefix":"10.1111","volume":"35","author":[{"given":"G.","family":"Paulis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"D\u2019Ascenzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Nupieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"De Giorgio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Orsolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Brancato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Alvaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874609811104020158"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1035336"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.08.009"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2011.02217.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65361-8"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1201\/9780203970140"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.05955.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)39746-X"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2010.24"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.08.064"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2006.01270.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2001.02241.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810962106"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.8.1951"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000049830"},{"key":"e_1_2_5_17_1","first-page":"171","article-title":"Clinical evaluation of the use of propoleum in Peyronie\u2019s disease","volume":"51","author":"Lemourt Oliva M","year":"1998","journal-title":"Arch Esp Urol"},{"key":"e_1_2_5_18_1","first-page":"805","article-title":"Propoleum and Peyronie\u2019s disease","volume":"56","author":"Lemourt Oliva M","year":"2003","journal-title":"Arch Esp Urol"},{"key":"e_1_2_5_19_1","first-page":"814","article-title":"Study of propoleum dosage in Peyronie\u2019s disease","volume":"56","author":"Lemourt Oliva M","year":"2003","journal-title":"Arch Esp Urol"},{"key":"e_1_2_5_20_1","first-page":"931","article-title":"Peyronie\u2019s disease. 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