{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:38:42Z","timestamp":1792741122930,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T00:00:00Z","timestamp":1340064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Andrology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Testosterone (T) and vitamin D (VD) interact in androgen deficient men, however, this interaction and subsequent semen quality and bone mineral density (BMD) status is not clear in infertile men. Our objective was to investigate T, VD, semen quality, BMD and their relationships in Chinese infertile men. We conducted a cross\u2010sectional study of 559 men aged 20\u201340\u2003years, including 195 fertile men, 9 infertile men with known risk factors for osteoporosis (WR) and 355 infertile men without known risk factors for osteoporosis (WOR). WOR infertile men constituted 314 oligo\u2010, astheno\u2010, teratospermic or normospermic infertile men (OATN men) and 41 non\u2010obstructive azoospermic men (NOA men). Differences of parameters were assessed, and the relationships were adjusted by multiple linear regression. WOR infertile men had significantly lower T, lumbar spine and total hip BMD than fertile men (all <jats:italic>p\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05). Bioavailable T (Bio\u2010T) and 25\u2010hydroxyvitamin D [25(OH)D] were independent determinants of BMD in WOR infertile men (all <jats:italic>p\u2003<\/jats:italic>&lt;\u20030.01) but not in fertile men. After stratifying Bio\u2010T, WOR infertile men had lower BMD than fertile men (all <jats:italic>p\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05) in low Bio\u2010T subgroups (Bio\u2010T\u2003\u2264\u200311.6\u2003nmol\/L), but not high Bio\u2010T subgroups (Bio\u2010T\u2003&gt;\u200311.6\u2003nmol\/L). 25(OH)D was an independent determinant of sperm motility and morphology in WOR OATN men (all <jats:italic>p\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05), with only borderline significance in fertile men(motility: <jats:italic>p\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.047; morphology: <jats:italic>p\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.056). T determined sperm concentration (square root) and morphology in WOR OATN men (all <jats:italic>p\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001). No correlations between T and 25(OH)D were found in all groups. We suggest that infertile men have lower T and BMD than fertile men. 25(OH)D and T were associated with low BMD and poor semen quality in infertile men.<\/jats:p>","DOI":"10.1111\/j.1365-2605.2012.01287.x","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T15:15:01Z","timestamp":1340118901000},"page":"783-792","source":"Crossref","is-referenced-by-count":75,"title":["Associations between testosterone, bone mineral density, vitamin D and semen quality in fertile and infertile Chinese men"],"prefix":"10.1111","volume":"35","author":[{"given":"B.","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)43575-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199301000-00011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200009001-00009"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1012141108"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031786"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2008.00975.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-7-140"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.11.2360"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(00)00336-2"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.12.029"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq024"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der059"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2012.01256.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.7.664"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.02.011"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-005-2039-5"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(86)90205-X"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223001124"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)44897-1"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2007.00197.x"},{"key":"e_1_2_8_22_1","first-page":"25","article-title":"Testosterone levels and bone mineral density in young healthy men and in young infertile patients","volume":"21","author":"Karasek M","year":"2000","journal-title":"Neuro Endocrinol Lett"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.4.8417"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.4.7403"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)59660-5"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0743"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)04679-4"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2008.11.015"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/7.11.1007"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.4.1102S"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.004"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66540-8"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1269854"},{"key":"e_1_2_8_34_1","first-page":"17","volume-title":"WHO Manual for the Standardized Investigation, Diagnosis and Management of the Infertile Male","author":"Rowe P","year":"2000"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602056"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00340-3"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2809"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.051"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-032187"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0765-1"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.10.6079"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03777.x"},{"key":"e_1_2_8_43_1","first-page":"4","volume-title":"WHO Laboratory Manual for the Examination of Human Semen and Sperm\u2010Cervical Mucus Interactions","author":"World Health Organization","year":"1999"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(03)00349-2"}],"container-title":["International Journal of Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2605.2012.01287.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2605.2012.01287.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/j.1365-2605.2012.01287.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2605.2012.01287.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T10:07:10Z","timestamp":1692612430000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2605.2012.01287.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,19]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/j.1365-2605.2012.01287.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2605.2012.01287.x","archive":["Portico"],"relation":{},"ISSN":["0105-6263","1365-2605"],"issn-type":[{"value":"0105-6263","type":"print"},{"value":"1365-2605","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,19]]}}}