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Micro\u2010clips were removed and glands were allowed to recover for periods of 8, 16 and 24\u2003weeks. Submandibular glands were stimulated with autonomimetic drugs (methacholine and isoprenaline) and salivas were collected from atrophic or de\u2010ligated and contralateral control glands. Glands recovered almost full size (92% of control gland) following 24\u2003weeks of de\u2010ligation. Saliva volume secreted by ligated\/de\u2010ligated (RSM) and control (LSM) glands were similar with different doses of agonists. Protein output expressed per gram of tissue wet weight was similar from both ligated\/de\u2010ligated and control glands with all doses of agonist. Sodium and chloride levels were higher from de\u2010ligated glands than contralateral control glands. Protein electrophoresis showed similar profiles of salivary proteins in all samples with some minor differences. Acinar cells in de\u2010ligated glands showed a normal morphology, as indicated by light microscopy, whilst granular ductal cells were fewer and contained fewer secretory granules. Sodium potassium ATPase staining of striated ducts in de\u2010ligated glands was similar to that of control glands. It can be concluded that rat submandibular glands can regenerate following severe atrophy and secrete normal amounts of saliva containing broadly a full profile of secretory proteins. In contrast to acinar cells, ductal cells appear not to recover full function.<\/jats:p>","DOI":"10.1111\/j.1365-2613.2006.00500.x","type":"journal-article","created":{"date-parts":[[2006,9,29]],"date-time":"2006-09-29T12:04:57Z","timestamp":1159531497000},"page":"411-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Recovery of rat submandibular salivary gland function following removal of obstruction: a sialometrical and sialochemical study"],"prefix":"10.1111","volume":"87","author":[{"given":"Samira M.","family":"Osailan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon B.","family":"Proctor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy H.","family":"Carpenter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine L.","family":"Paterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"McGurk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(78)90094-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.10.1.56"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.1o816.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020746"},{"key":"e_1_2_6_6_1","first-page":"60","article-title":"Quantitative determination of protein in saliva","volume":"79","author":"Arneberg P.","year":"1971","journal-title":"Scand. 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