{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:44:32Z","timestamp":1762271072097},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T00:00:00Z","timestamp":1166572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The responses of animal experimental models related to the infectivity, virulence and pathogenicity of <jats:italic>Paracoccidioides brasiliensis<\/jats:italic> is constantly used to develop new perspectives of investigation. The rodent <jats:italic>Calomys callosus<\/jats:italic>, Rengger 1830 (Rodentia: Cricetidae) is an indigenous inhabitant of the savannah environment found in the central regions of Brazil. The aim of the present work was to evaluate the histopathological and serological features of <jats:italic>C.\u00a0callosus<\/jats:italic> after inoculation with the Pb18 strain of <jats:italic>P.\u00a0brasiliensis<\/jats:italic>. Furthermore, A\/Sn and B10.A mice strains were also tested to compare the results obtained in <jats:italic>C.\u00a0callosus<\/jats:italic> to these well\u2010established experimental models of resistance and susceptibility respectively. In every instance, survival analysis was performed, and histopathological study of the lungs, liver and spleen was employed to investigate tissue involvement, degree of inflammation and fungal presence. Levels of antibodies to <jats:italic>P.\u00a0brasiliensis<\/jats:italic> were measured by using an enzyme\u2010linked immunosorbent assay after 4\u2003weeks and at the advanced stage of infection. The mortality rate was proportional to inoculation dose in all groups, but overall it was much superior in <jats:italic>C.\u00a0callosus<\/jats:italic> than in the B10.A\u2010susceptible mice. Macroscopical and microscopical pathological alterations were also more extensive and remarkable for <jats:italic>C.\u00a0callosus<\/jats:italic>, once again proportional to inoculation dose, but more noticeable differences among the studied groups were found with 0.6\u2003\u00d7\u200310<jats:sup>5<\/jats:sup> inoculum. In addition, the serological profile of <jats:italic>C.\u00a0callosus<\/jats:italic> was similar to that found for B10.A\u2010susceptible mice. Infection of <jats:italic>C.\u00a0callosus<\/jats:italic> with 0.6\u2003\u00d7\u200310<jats:sup>8<\/jats:sup> Pb18 inoculum resulted in more serious illness, and it decreased in severity in proportion to the inoculum dose. This difference was more pronounced in <jats:italic>C.\u00a0callosus<\/jats:italic>, and the clinical, serological and pathological findings in this animal were more intense and precocious compared with the B10.A\u2010susceptible mice. The present results suggest that <jats:italic>C.\u00a0callosus<\/jats:italic> is a potentially alternative experimental animal model for paracoccidioidomycosis infection.<\/jats:p>","DOI":"10.1111\/j.1365-2613.2006.00513.x","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T07:52:22Z","timestamp":1166687542000},"page":"55-62","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Histological and serological evidence of experimental paracoccidioidomycosis in <i>Calomys callosus<\/i> (Rodentia: Cricetidae)"],"prefix":"10.1111","volume":"88","author":[{"given":"Alceu L.C.V.","family":"Berbert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele G.","family":"Faria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margareth L.","family":"Gennari\u2010Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria M.M.D.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 R.","family":"Mineo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano M.","family":"Loyola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761994000300017"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1996.55.391"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00683967"},{"key":"e_1_2_7_5_1","first-page":"585","article-title":"Susceptibility and resistance of inbred mice to Paracoccidioides brasiliensis","volume":"66","author":"Calich V.L.G.","year":"1985","journal-title":"Br. 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