{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T05:50:21Z","timestamp":1697176221096},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,1,22]],"date-time":"2007-01-22T00:00:00Z","timestamp":1169424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Previous studies of experimental <jats:italic>Bacillus anthracis<\/jats:italic> cutaneous infections in mice have implicated hair follicles as a likely entry site. Hairless HRS\/J mice were used to investigate this possibility because of their non\u2010functional hair follicles that lack penetrating hair shafts. These mice also have diminished macrophage function, increased susceptibility to <jats:italic>Listeria<\/jats:italic>, and enhanced neutrophil responses. HRS\/J and Balb\/c mice were found to be resistant to epicutaneous inoculation with <jats:italic>Bacillus anthracis<\/jats:italic> (Sterne) spores onto abraded skin when compared with DBA\/2 mice or leucopenic C57BL\/6 mice. The HRS\/J mice also resisted spore injections that bypassed hair follicles. Haired HRS\/J heterozygote mice demonstrated similar reduced susceptibility to <jats:italic>B. anthracis<\/jats:italic> spores. Hairless HRS\/J mice that were made leucopenic did become susceptible to the epicutaneous spore inoculations. Histologically, the hairless and haired HRS\/J mice showed markedly reduced numbers of organisms in hair follicles and the interfollicular dermis when compared even with the resistant Balb\/c mice; inflammatory cell infiltrates in the superficial dermis were increased in the HRS\/J mice compared with more sensitive strains. Therefore, resistance in the HRS\/J mice was apparent at the initial site of epicutaneous inoculation and seemed related to an accumulation of dermal neutrophils rather than to a lack of functional hair follicles.<\/jats:p>","DOI":"10.1111\/j.1365-2613.2006.00519.x","type":"journal-article","created":{"date-parts":[[2007,1,22]],"date-time":"2007-01-22T10:49:50Z","timestamp":1169462990000},"page":"75-84","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Experimental cutaneous Bacillus anthracis infections in hairless HRS\/J mice"],"prefix":"10.1111","volume":"88","author":[{"given":"Timothy S.","family":"Bischof","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth L.","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G.","family":"Sohnle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1993.tb03861.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1128\/iai.56.3.607-612.1988","article-title":"Susceptibility of HRS\/J mice to listeriosis \u2013 dynamics of infection","volume":"56","author":"Archinal W.A.","year":"1988","journal-title":"Infect. 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